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ABCG8
Gene Name
ATP-binding cassette, sub-family G (WHITE), member 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Apical Plasma Membrane
ATP-binding Cassette (ABC) Transporter Complex
Receptor Complex
Molecular Function
Protein Binding
ATP Binding
ATPase Activity
Cholesterol Transporter Activity
Protein Heterodimerization Activity
Biological Process
Response To Nutrient
Excretion
Negative Regulation Of Intestinal Phytosterol Absorption
Phospholipid Transport
Sterol Transport
Intestinal Cholesterol Absorption
Cholesterol Efflux
Response To Drug
Cholesterol Homeostasis
Small Molecule Metabolic Process
Negative Regulation Of Intestinal Cholesterol Absorption
Transmembrane Transport
Pathways
Metabolism of lipids and lipoproteins
ABC-family proteins mediated transport
Lipid digestion, mobilization, and transport
Trafficking of dietary sterols
ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS
Cholesterol, total (
20686565
)
Gallstones (
17632509
)
LDL cholesterol (
23726366
19060906
20686565
)
Lipid metabolism phenotypes (
19936222
)
Phytosterol levels (
20529992
)
Protein-protein Interactions
8 interactors:
ABCG5
AGPAT2
AKT2
ANG
LMNB1
MAL2
NR4A1
NUPR1
Entrez ID
64241
HPRD ID
05679
Ensembl ID
ENSG00000143921
Uniprot IDs
Q9H221
PDB IDs
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Lipid Transport
Apoptotic Process
Programmed Cell Death
Cell Death
Skeletal Muscle Cell Differentiation
Death
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Endothelial Cell Proliferation
Regulation Of Lipid Transport
Neutral Lipid Metabolic Process
Negative Regulation Of Intestinal Phytosterol Absorption
Negative Regulation Of Intestinal Cholesterol Absorption
Skeletal Muscle Tissue Development
Skeletal Muscle Organ Development
Tissue Development
Positive Regulation Of Epithelial Cell Proliferation
Diacylglycerol Biosynthetic Process
Activation Of Ral GTPase Activity
Activation Of Phospholipase A2 Activity
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phospholipase A2 Activity
Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Positive Regulation Of Protein Modification Process
Response To Hormone
Positive Regulation Of Ral GTPase Activity
Regulation Of Ral Protein Signal Transduction
Gonad Development
Regulation Of Protein Metabolic Process
Development Of Primary Sexual Characteristics
Intestinal Cholesterol Absorption
Regulation Of Intestinal Cholesterol Absorption
Regulation Of Translation
Muscle Organ Development
Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Cellular Protein Metabolic Process
Sex Differentiation
Regulation Of Glucose Import In Response To Insulin Stimulus
Negative Regulation Of Cholesterol Transport
Positive Regulation Of Fatty Acid Beta-oxidation
CDP-diacylglycerol Biosynthetic Process
Positive Regulation Of Vesicle Fusion
Regulation Of Phospholipase A2 Activity
Striated Muscle Tissue Development
Positive Regulation Of Cellular Metabolic Process
Regulation Of Female Gonad Development
CDP-diacylglycerol Metabolic Process
Lipid Digestion
Positive Regulation Of Protein Transport
Angiogenesis
Tagcloud
?
abca1
abcg5
atorvastatin
causal
challenging
chow
excised
fads1
gwas
hfd
hypertensive
list
loci
lpl
madd
nominally
nr1h3
orthologs
overlapped
pcsk9
pltp
qpcr
qtl
responded
spontaneously
stac3
staged
suggestive
timd4