SIRPA

Gene Name		signal-regulatory protein alpha
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	SH3 Domain Binding
	Biological Process	Cell Adhesion Blood Coagulation Leukocyte Migration
Pathways		Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Mean platelet volume ( 22139419 19820697)
Protein-protein Interactions		12 interactors: CCDC57 CD47 IL1RAP JAK2 KRT15 KRT31 KRT40 NOL3 PTPN11 PTPN6 TRIM2 TRIM27
Entrez ID		140885
HPRD ID		03912
Ensembl ID		ENSG00000198053
Uniprot IDs		P78324
PDB IDs		2JJS 2JJT 2UV3 2WNG
Enriched GO Terms of Interacting Partners?		Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Abortive Mitotic Cell Cycle Response To Wounding Positive Regulation Of Cell Activation Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Megakaryocyte Development Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Cell Activation Platelet Formation Platelet Morphogenesis Megakaryocyte Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Negative Regulation Of Cell Adhesion Wound Healing Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Immune System Process Immune Response Regulation Of Immune System Process Leukocyte Migration Negative Regulation Of Adaptive Immune Response Response To Stress Defense Response Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Growth Hormone Myeloid Cell Differentiation Regulation Of Type I Interferon-mediated Signaling Pathway Response To Cytokine Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Regulation Of Kinase Activity JAK-STAT Cascade
Tagcloud ?		accelerated cd47 concert demonstrates diabetogenic displayed drive drives enables encodes idd13 idd5 immunopathogenesis insight insulitis islet locus mechanistic nod paired potency potentiate recapitulates restricted t1d transgene variations