SIRPA and GNL1

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		SIRPA	GNL1
Description		signal regulatory protein alpha	G protein nucleolar 1 (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Space Nucleus
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding	Nucleotide Binding GTPase Activity Structural Molecule Activity GTP Binding
	Biological Process	Cell Adhesion Regulation Of Gene Expression Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Cell-cell Adhesion Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process	T Cell Mediated Immunity DNA Damage Response Signal Transduction
Pathways		Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 19820697 22139419 27863252 32888494) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Lung cancer ( 28604730) Major depressive disorder ( 27479909) Neuroticism ( 29255261) Rosacea symptom severity ( 29771307) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM	5 interacting genes: GDI1 PTP4A1 SIRPA VPS35 ZNF212
Entrez ID		140885	2794
HPRD ID		03912	00879
Ensembl ID		ENSG00000198053	ENSG00000204590
Uniprot IDs		P78324	A0A024RCR2 B4DYK6 P36915
PDB IDs		2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV 7KPG 7ST5 7YGG
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Focal Adhesion Supramolecular Fiber Organization ATP-dependent Protein Folding Chaperone Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Folding Chaperone Structural Constituent Of Skin Epidermis Cytoplasm Keratin Filament Nucleotide Binding Intermediate Filament Unfolded Protein Binding Structural Molecule Activity Cytoskeleton Organization Protein Folding Protein Folding In Endoplasmic Reticulum Non-membrane Spanning Protein Tyrosine Phosphatase Activity Maintenance Of Location Plasma Membrane Bounded Cell Projection Organization Organelle Organization Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Cadherin Binding T Cell Costimulation Protein Metabolic Process Protein Binding Platelet Formation Regulation Of Nitric Oxide Biosynthetic Process RNA Binding Response To Interleukin-12 Megakaryocyte Development Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Metabolic Process Heat Shock Protein Binding Regulation Of Nitric Oxide Metabolic Process Epithelial Cell Differentiation ATP Binding MHC Class II Protein Complex Binding Cell Projection Organization Sequestering Of Calcium Ion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Maintenance Of Location In Cell Protein Modification Process Glutamatergic Synapse Cytoskeleton	Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Diamide Cellular Response To Sodium Arsenite Vesicle-mediated Transport To The Plasma Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Protein Targeting To Membrane Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Entry Of Bacterium Into Host Cell Neuromuscular Process General Adaptation Syndrome, Behavioral Process Positive Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Protein Homooligomerization Mitochondrion-derived Vesicle Positive Regulation Of Wnt Protein Secretion Regulation Of Locomotion Involved In Locomotory Behavior Tubular Endosome Negative Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Dopamine Metabolic Process Retromer, Cargo-selective Complex Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Voluntary Musculoskeletal Movement Regulation Of Terminal Button Organization Regulation Of Dopamine Biosynthetic Process Mitochondrion To Lysosome Vesicle-mediated Transport Negative Regulation Of Protein Oligomerization Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Protein Binding Involved In Heterotypic Cell-cell Adhesion Cellular Response To Interleukin-12 Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Interleukin-12 Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Monocyte Extravasation Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Entry Of Bacterium Into Host Cell D1 Dopamine Receptor Binding Negative Regulation Of Inflammatory Response Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Protein Antigen Binding Neurotransmitter Receptor Transport To Postsynaptic Membrane Mitochondrial Fragmentation Involved In Apoptotic Process Establishment Of Protein Localization To Postsynaptic Membrane Regulation Of Lysosomal Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway
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