SIRPA and EIF5B

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		SIRPA	EIF5B
Description		signal regulatory protein alpha	eukaryotic translation initiation factor 5B
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding	TRNA Binding Nucleotide Binding RNA Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Cell Adhesion Regulation Of Gene Expression Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Cell-cell Adhesion Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process	Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly
Pathways		Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 19820697 22139419 27863252 32888494) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Bipolar disorder ( 21926972)
Interacting Genes		60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM	14 interacting genes: BRCA1 CBL CDC42 CEBPA CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 SIRPA SRSF12 TFCP2 WBP4 ZBTB3
Entrez ID		140885	9669
HPRD ID		03912	07304
Ensembl ID		ENSG00000198053	ENSG00000158417
Uniprot IDs		P78324	O60841 Q8N5A0
PDB IDs		2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV 7KPG 7ST5 7YGG	7TQL 8PJ3 8PJ4 8PJ5
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Focal Adhesion Supramolecular Fiber Organization ATP-dependent Protein Folding Chaperone Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Folding Chaperone Structural Constituent Of Skin Epidermis Cytoplasm Keratin Filament Nucleotide Binding Intermediate Filament Unfolded Protein Binding Structural Molecule Activity Cytoskeleton Organization Protein Folding Protein Folding In Endoplasmic Reticulum Non-membrane Spanning Protein Tyrosine Phosphatase Activity Maintenance Of Location Plasma Membrane Bounded Cell Projection Organization Organelle Organization Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Cadherin Binding T Cell Costimulation Protein Metabolic Process Protein Binding Platelet Formation Regulation Of Nitric Oxide Biosynthetic Process RNA Binding Response To Interleukin-12 Megakaryocyte Development Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Metabolic Process Heat Shock Protein Binding Regulation Of Nitric Oxide Metabolic Process Epithelial Cell Differentiation ATP Binding MHC Class II Protein Complex Binding Cell Projection Organization Sequestering Of Calcium Ion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Maintenance Of Location In Cell Protein Modification Process Glutamatergic Synapse Cytoskeleton	Response To Ionizing Radiation Regulation Of Cell Cycle Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Endocytosis Response To Radiation Protein Tyrosine Kinase Binding RNA Metabolic Process Positive Regulation Of Cytokinesis Macrophage Differentiation Response To Peptide Response To Cytokine DNA Recombination RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Protein Autoubiquitination BRCA1-BARD1 Complex GBD Domain Binding Storage Vacuole Cellular Response To Type II Interferon Positive Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex MRNA Metabolic Process Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-12 BRCA1-B Complex Positive Regulation Of Metabolic Process DNA Damage Response Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Protein-containing Complex Regulation Of Macromolecule Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II
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