SIRPA and KRT10

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		SIRPA	KRT10
Description		signal regulatory protein alpha	keratin 10
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Cell Surface Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity
	Biological Process	Cell Adhesion Regulation Of Gene Expression Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Cell-cell Adhesion Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process	Morphogenesis Of An Epithelium Peptide Cross-linking Keratinocyte Differentiation Intermediate Filament Organization Positive Regulation Of Epidermis Development Protein Heterotetramerization
Pathways		Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs			Zinc Copper Zinc acetate
Diseases			Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Ichthyosis with confetti; Congenital reticular ichthyosiform erythroderma; Ichthyosis variegata
GWAS		Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 19820697 22139419 27863252 32888494) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Glucose homeostasis traits ( 25524916)
Interacting Genes		60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM	10 interacting genes: AKT1 ESR1 EVPL GLE1 OGT PRKCZ RNF26 SIRPA SMAD3 SNAPIN
Entrez ID		140885	3858
HPRD ID		03912	01021
Ensembl ID		ENSG00000198053	ENSG00000186395
Uniprot IDs		P78324	A0A1B0GVI3 P13645
PDB IDs		2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV 7KPG 7ST5 7YGG	3ASW 4F1Z 4ZRY 6E2J 6EC0 6UUI
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Focal Adhesion Supramolecular Fiber Organization ATP-dependent Protein Folding Chaperone Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Folding Chaperone Structural Constituent Of Skin Epidermis Cytoplasm Keratin Filament Nucleotide Binding Intermediate Filament Unfolded Protein Binding Structural Molecule Activity Cytoskeleton Organization Protein Folding Protein Folding In Endoplasmic Reticulum Non-membrane Spanning Protein Tyrosine Phosphatase Activity Maintenance Of Location Plasma Membrane Bounded Cell Projection Organization Organelle Organization Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Cadherin Binding T Cell Costimulation Protein Metabolic Process Protein Binding Platelet Formation Regulation Of Nitric Oxide Biosynthetic Process RNA Binding Response To Interleukin-12 Megakaryocyte Development Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Metabolic Process Heat Shock Protein Binding Regulation Of Nitric Oxide Metabolic Process Epithelial Cell Differentiation ATP Binding MHC Class II Protein Complex Binding Cell Projection Organization Sequestering Of Calcium Ion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Maintenance Of Location In Cell Protein Modification Process Glutamatergic Synapse Cytoskeleton	Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Nitric-oxide Synthase Regulator Activity Intracellular Protein Localization Response To Hormone Response To Peptide Hormone Ciliary Basal Body Negative Regulation Of Cellular Component Organization Regulation Of Immune System Process Regulation Of Immune Response Response To Insulin Negative Regulation Of MiRNA Transcription Organelle Organization Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Maternal Process Involved In Female Pregnancy 14-3-3 Protein Binding Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Gene Expression Phosphatidylinositol-3,4,5-trisphosphate Binding Protein K11-linked Ubiquitination Protein Metabolic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Positive Regulation Of T Cell Activation Transcription Coactivator Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Defense Response Regulation Of TRNA Methylation Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Late Endosome To Lysosome Transport Cellular Response To Glucose Stimulus TORC1 Signaling Negative Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Positive Regulation Of TORC1 Signaling Protein Maturation Regulation Of Cell Adhesion
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