FLI1 and ERG

Number of citations of the paper that reports this interaction (PMID 9681824)
14

Data Source:
HPRD (in vitro)

		FLI1	ERG
Gene Name		Fli-1 proto-oncogene, ETS transcription factor	v-ets avian erythroblastosis virus E26 oncogene homolog
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Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Hemostasis Blood Circulation Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Height ( 20881960) Myopia (pathological) ( 23049088) Rheumatoid arthritis ( 22446963)	Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)
Protein-Protein Interactions		19 interactors: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF SUMO1 TDP2 UBE2I	61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2
Entrez ID		2313	2078
HPRD ID		01901	01298
Ensembl ID		ENSG00000151702	ENSG00000157554
Uniprot IDs		Q01543	B4DN83 B4DVX5 P11308
PDB IDs		1FLI 1X66 2YTU	1SXE 4IRG 4IRH 4IRI
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Sumoylation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Binding Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Signaling Erythrocyte Development Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Developmental Process Metabolic Process Peptidyl-lysine Modification Peptidyl-amino Acid Modification	MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed