MT-ND1

Name	NADH dehydrogenase subunit 1
Structure
Interactors	13 interactors: BARD1 BRCA1 DHDDS FAT1 LIG4 MEOX2 NDUFS7 PAXIP1 RPL13A RPL6 SIRPA TSC1 TST
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Respiratory Chain Complex I
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Response To Hypoxia Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Response To Xenobiotic Stimulus Mitochondrial Respiratory Chain Complex I Assembly Response To Hydroperoxide Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways	Mitochondrial translation termination Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate
Diseases	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS	No GWAS studies recorded
Entrez ID	4535
HPRD ID	08365
Ensembl ID	ENSG00000198888
Uniprot IDs	P03886 U5Z754
PDB IDs	5XTC 5XTD
GO Terms Enriched among Interactors ?	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Response To Ionizing Radiation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cell Cycle G2/M Phase Transition Large Ribosomal Subunit Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Cellular Response To Radiation Response To Radiation Condensed Chromosome Homologous Recombination DNA Repair Mitotic G2/M Transition Checkpoint Cellular Response To Stress Negative Regulation Of MRNA 3'-end Processing Establishment Of Epithelial Cell Apical/basal Polarity Involved In Camera-type Eye Morphogenesis Establishment Of Integrated Proviral Latency Memory T Cell Differentiation Negative Regulation Of Formation Of Translation Preinitiation Complex Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Cytosolic Large Ribosomal Subunit Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Establishment Of Viral Latency Cyanate Catabolic Process 3-mercaptopyruvate Sulfurtransferase Activity Negative Regulation Of Cytoplasmic Translational Initiation Cellular Response To Type II Interferon Cellular Response To Interleukin-12 DNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Ubiquitin Ligase Complex DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoprotein Complex DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination