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TRIM32 and TOP1
Number of citations of the paper that reports this interaction (PubMedID
12549820
)
0
Data Source:
BioGRID
(unspecified method)
TRIM32
TOP1
Description
tripartite motif containing 32
DNA topoisomerase I
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Autophagosome
Endoplasmic Reticulum
Centrosome
Cytosol
Striated Muscle Myosin Thick Filament
Nuclear Chromosome
P-body
Fibrillar Center
Dense Fibrillar Component
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Protein-DNA Complex
Perikaryon
Molecular Function
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Myosin Binding
Protein-macromolecule Adaptor Activity
Tat Protein Binding
Translation Initiation Factor Binding
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
RNA Binding
DNA Topoisomerase Activity
DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
DNA Binding, Bending
Isomerase Activity
Protein Domain Specific Binding
Chromatin DNA Binding
Protein-containing Complex Binding
Supercoiled DNA Binding
Biological Process
Autophagosome Assembly
Protein Polyubiquitination
Tissue Homeostasis
Ubiquitin-dependent Protein Catabolic Process
Response To Oxidative Stress
Actin Ubiquitination
Response To UV
Positive Regulation Of Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Cellular Homeostasis
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Viral Transcription
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Amino Acid Starvation
Response To Tumor Necrosis Factor
Response To Starvation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Suppression Of Viral Release By Host
Innate Immune Response
Fat Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Cycle
Positive Regulation Of Proteolysis
Positive Regulation Of DNA-templated Transcription
Muscle Cell Cellular Homeostasis
Negative Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Striated Muscle Cell Differentiation
Positive Regulation Of Protein Metabolic Process
Cilium Assembly
Axon Development
Cytosolic Ciliogenesis
Protein K63-linked Ubiquitination
Negative Regulation Of Cilium Assembly
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production
Protein Localization To Phagocytic Vesicle
Positive Regulation Of Cell Motility
Positive Regulation Of Autophagosome Assembly
DNA Replication
DNA Topological Change
Chromatin Remodeling
Chromosome Segregation
Circadian Rhythm
Response To Temperature Stimulus
RRNA Transcription
Response To Xenobiotic Stimulus
Response To Gamma Radiation
Programmed Cell Death
Peptidyl-serine Phosphorylation
Animal Organ Regeneration
Circadian Regulation Of Gene Expression
Embryonic Cleavage
Rhythmic Process
Response To CAMP
Cellular Response To Luteinizing Hormone Stimulus
Pathways
Regulation of innate immune responses to cytosolic DNA
Antigen processing: Ubiquitination & Proteasome degradation
SUMOylation of DNA replication proteins
Drugs
Irinotecan
Dactinomycin
Doxorubicin
Topotecan
Camptothecin
Edotecarin
Lucanthone
Elsamitrucin
7-ethyl-10-hydroxycamptothecin
Sodium stibogluconate
Cositecan
XMT-1001
Rubitecan
2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Hexylresorcinol
Sacituzumab govitecan
Trastuzumab deruxtecan
Diseases
Bardet-Biedl syndrome (BBS)
GWAS
Estimated glomerular filtration rate (
31015462
)
Hip circumference adjusted for BMI (
34021172
)
Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) (
28560309
)
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Brain morphology (MOSTest) (
32665545
)
Cholesterol, total (
24097068
20686565
)
Hemoglobin (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
LDL cholesterol (
20686565
24097068
)
LDL cholesterol levels (
28334899
)
LDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
LDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Male-pattern baldness (
28196072
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Total cholesterol levels (
28334899
)
Urate levels (
31578528
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
62 interacting genes:
ABI2
ATXN1
BTG3
CFTR
CLIP4
DERL1
ERGIC3
FADS6
GABARAP
GABARAPL1
GABARAPL2
GEM
GLIS2
GPR137B
HSPA4
ICMT
IQCB1
IRAK1
KCTD9
LCN2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MID2
MOB1A
MYCN
NDRG2
NTAQ1
PDE9A
PELI2
PIAS3
PIAS4
PTCD2
PTPN11
RAB29
RABAC1
RNF208
RNF41
SCGB1A1
SDCBP
SYT6
TCEANC
TOP1
TRIM23
TRIM27
TRIM5
TRIM72
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBE2V1
UBQLN1
UBQLN4
VPS11
XIAP
59 interacting genes:
APAF1
APP
ATM
BARD1
BRCA1
BRD2
BTBD1
BTBD2
BUB3
CASP3
CASP6
CDK8
CEBPA
CKAP5
CSNK2A1
CSNK2A2
DDB2
ELK3
ERCC8
ERG
FSHR
GEMIN4
IL7R
IRF4
IRF8
IRF9
JAK1
JUN
LIG4
LSM4
MDM2
NCL
NCOA6
PDE10A
PIAS4
PPP2R2B
PRB1
PYGM
RBL1
RBL2
RCVRN
SF3B1
SFPQ
SNW1
SRPK2
SRSF1
SRSF11
SUMO1
SYMPK
TARBP2
TDP1
TIAM1
TOPORS
TP53
TRIM32
TUBD1
U2AF2
UBE2I
XRCC5
Entrez ID
22954
7150
HPRD ID
03797
00535
Ensembl ID
ENSG00000119401
ENSG00000198900
Uniprot IDs
Q13049
P11387
Q9BVT2
PDB IDs
2CT2
5FEY
1A31
1A35
1A36
1EJ9
1K4S
1K4T
1LPQ
1NH3
1R49
1RR8
1RRJ
1SC7
1SEU
1T8I
1TL8
Enriched GO Terms of Interacting Partners
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Ubiquitin Conjugating Enzyme Activity
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Protein Ubiquitination
Cellular Response To Nitrogen Starvation
Protein Polyubiquitination
Protein Modification Process
Phosphatidylethanolamine Binding
Ubiquitin-protein Transferase Activity
Autophagosome
Ubiquitin Protein Ligase Activity
Autophagy
Protein Metabolic Process
Autophagosome Maturation
Positive Regulation Of Post-translational Protein Modification
Mitophagy
Positive Regulation Of Protein Polyubiquitination
Protein K63-linked Ubiquitination
Autophagy Of Mitochondrion
Ubiquitin Protein Ligase Binding
Autophagosome Membrane
Cellular Response To Nutrient Levels
Regulation Of Protein Polyubiquitination
Autophagosome Assembly
Protein-containing Complex Disassembly
Response To Stress
Cellular Response To Stress
Autophagosome Organization
Catabolic Process
Positive Regulation Of Protein Ubiquitination
Macroautophagy
Vacuole Organization
Regulation Of Post-translational Protein Modification
Protein Binding
Macromolecule Metabolic Process
Cytoplasmic Vesicle
Positive Regulation Of Protein Modification Process
Modification-dependent Protein Catabolic Process
Protein Monoubiquitination
Proteolysis Involved In Protein Catabolic Process
Protein K48-linked Ubiquitination
Phospholipid Binding
Transferase Activity
Regulation Of Protein Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Actin Nucleation
Positive Regulation Of Protein Metabolic Process
Response To Nutrient Levels
Regulation Of Macromolecule Metabolic Process
Organelle Membrane
Nucleoplasm
Nucleus
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Regulation Of RNA Metabolic Process
Macromolecule Metabolic Process
DNA Repair
Response To Ionizing Radiation
Response To Radiation
Nucleobase-containing Compound Metabolic Process
Response To Stress
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Regulation Of Macromolecule Biosynthetic Process
Response To X-ray
Regulation Of Programmed Cell Death
Regulation Of Metabolic Process
Chromatin
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Enzyme Binding
MRNA Metabolic Process
Cellular Response To Radiation
Positive Regulation Of Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway
DNA Metabolic Process
DNA Topoisomerase Binding
Nuclear Speck
Cellular Developmental Process
Positive Regulation Of Apoptotic Process
Transcription Cis-regulatory Region Binding
Negative Regulation Of Cell Cycle
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein-RNA Complex Assembly
Protein Polyubiquitination
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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