TRIM32 and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 31685529)
71

Data Source:
BioGRID (pull down)

		TRIM32	GABARAPL2
Description		tripartite motif containing 32	GABA type A receptor associated protein like 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Centrosome Cytosol Striated Muscle Myosin Thick Filament	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Myosin Binding Protein-macromolecule Adaptor Activity Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Actin Ubiquitination Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Cellular Homeostasis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Viral Transcription Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Tumor Necrosis Factor Response To Starvation Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Cilium Assembly Axon Development Cytosolic Ciliogenesis Protein K63-linked Ubiquitination Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Motility Positive Regulation Of Autophagosome Assembly	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy TBC/RABGAPs
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 34021172)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		62 interacting genes: ABI2 ATXN1 BTG3 CFTR CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN4 VPS11 XIAP	103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		22954	11345
HPRD ID		03797	16246
Ensembl ID		ENSG00000119401	ENSG00000034713
Uniprot IDs		Q13049	P60520
PDB IDs		2CT2 5FEY	4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Cellular Response To Nitrogen Starvation Protein Polyubiquitination Protein Modification Process Phosphatidylethanolamine Binding Ubiquitin-protein Transferase Activity Autophagosome Ubiquitin Protein Ligase Activity Autophagy Protein Metabolic Process Autophagosome Maturation Positive Regulation Of Post-translational Protein Modification Mitophagy Positive Regulation Of Protein Polyubiquitination Protein K63-linked Ubiquitination Autophagy Of Mitochondrion Ubiquitin Protein Ligase Binding Autophagosome Membrane Cellular Response To Nutrient Levels Regulation Of Protein Polyubiquitination Autophagosome Assembly Protein-containing Complex Disassembly Response To Stress Cellular Response To Stress Autophagosome Organization Catabolic Process Positive Regulation Of Protein Ubiquitination Macroautophagy Vacuole Organization Regulation Of Post-translational Protein Modification Protein Binding Macromolecule Metabolic Process Cytoplasmic Vesicle Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Phospholipid Binding Transferase Activity Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Nucleation Positive Regulation Of Protein Metabolic Process Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process Organelle Membrane	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
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