TRIM32 and ICMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM32	ICMT
Description		tripartite motif containing 32	isoprenylcysteine carboxyl methyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Centrosome Cytosol Striated Muscle Myosin Thick Filament	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Myosin Binding Protein-macromolecule Adaptor Activity Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Actin Ubiquitination Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Cellular Homeostasis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Viral Transcription Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Tumor Necrosis Factor Response To Starvation Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Cilium Assembly Axon Development Cytosolic Ciliogenesis Protein K63-linked Ubiquitination Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Motility Positive Regulation Of Autophagosome Assembly	C-terminal Protein Methylation Protein Targeting To Membrane Nuclear Envelope Organization Methylation Protein Modification Process S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Protein Maturation
Pathways		Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation RAS processing
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 34021172)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)
Interacting Genes		62 interacting genes: ABI2 ATXN1 BTG3 CFTR CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN4 VPS11 XIAP	12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32
Entrez ID		22954	23463
HPRD ID		03797	09321
Ensembl ID		ENSG00000119401	ENSG00000116237
Uniprot IDs		Q13049	B3KS61 O60725 Q7Z750
PDB IDs		2CT2 5FEY
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Cellular Response To Nitrogen Starvation Protein Polyubiquitination Protein Modification Process Phosphatidylethanolamine Binding Ubiquitin-protein Transferase Activity Autophagosome Ubiquitin Protein Ligase Activity Autophagy Protein Metabolic Process Autophagosome Maturation Positive Regulation Of Post-translational Protein Modification Mitophagy Positive Regulation Of Protein Polyubiquitination Protein K63-linked Ubiquitination Autophagy Of Mitochondrion Ubiquitin Protein Ligase Binding Autophagosome Membrane Cellular Response To Nutrient Levels Regulation Of Protein Polyubiquitination Autophagosome Assembly Protein-containing Complex Disassembly Response To Stress Cellular Response To Stress Autophagosome Organization Catabolic Process Positive Regulation Of Protein Ubiquitination Macroautophagy Vacuole Organization Regulation Of Post-translational Protein Modification Protein Binding Macromolecule Metabolic Process Cytoplasmic Vesicle Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Phospholipid Binding Transferase Activity Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Nucleation Positive Regulation Of Protein Metabolic Process Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process Organelle Membrane	Telencephalon Cell Migration Forebrain Cell Migration GTPase Activity GTP Binding Erythrocyte Enucleation Positive Regulation Of Cellular Component Biogenesis G Protein Activity Regulation Of Cell Projection Assembly Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Positive Regulation Of Locomotion Positive Regulation Of Ruffle Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Chemotaxis Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Locomotion Regulation Of Respiratory Burst Actin Cytoskeleton Organization Cell Projection Assembly Respiratory Burst Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Superoxide Anion Generation Response To External Biotic Stimulus Positive Regulation Of Neutrophil Chemotaxis Myosin Binding Actin Filament-based Process Positive Regulation Of Leukocyte Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Lamellipodium Assembly Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Wnt Signaling Pathway, Planar Cell Polarity Pathway Tissue Homeostasis Anatomical Structure Homeostasis Positive Regulation Of Lamellipodium Organization Cell Morphogenesis Lamellipodium Regulation Of Neuron Differentiation Membrane
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