PRDM6 and ELOA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRDM6	ELOA
Description		PR/SET domain 6	elongin A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Space Nucleus Nucleoplasm Elongin Complex Site Of DNA Damage
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Identical Protein Binding Metal Ion Binding Histone H4K20 Monomethyltransferase Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Neurogenesis Methylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Body mass index ( 28892062) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072) Mammographic density (dense area) ( 25342443) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Percent mammographic density ( 25342443) Pulse pressure ( 27841878 27618447) QRS duration ( 25035420) Systolic blood pressure ( 27841878 27618447 26390057 30578418)
Interacting Genes		71 interacting genes: ABI2 AGXT AHCYL1 AIRIM ANKS1A AQP1 ARID5A ATOSB ATPAF2 ATXN7L2 BAG3 BANF2 BANP CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A SLC19A4P STK16 TCAF1 TEKT4 TLE5 TRIM14 TSGA10 TSGA10IP TSSK3 TTC23 TYW2 UBASH3A USP54 ZFYVE26	58 interacting genes: AXIN2 BACH2 BRCA1 CBY2 CCDC57 CDR2L CEP57L1 CEP70 CNTROB CUL5 DLGAP1-AS2 ELOB ERCC6 EVI5 FAM9B FCHO1 FXR1 GMCL1 GOLGA6A GRIPAP1 HIVEP1 HOMEZ JAKMIP2 KANK2 KLHL2 KRT40 KRTAP10-3 KXD1 LMNA LZTS1 MCC MDFI MED21 MID1 MID2 NAB2 NACC1 NAF1 NFKBID NINL OGT PER2 PLK4 PPFIA1 PRDM6 PRMT5 RABEP1 RAD54B RAP1A REXO1 RNF10 SIRPA SPECC1L TNIP1 TP53BP2 TRIM37 TRIM54 ZNF792
Entrez ID		93166	6924
HPRD ID		19698	02873
Ensembl ID		ENSG00000061455	ENSG00000011007
Uniprot IDs		Q9NQX0	Q14241
PDB IDs			4HFX 6ZUZ 8OEV 8OEW 8OF0
Enriched GO Terms of Interacting Partners?		Protein Binding	Negative Regulation Of Cytoskeleton Organization Identical Protein Binding Regulation Of Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Negative Regulation Of RNA Metabolic Process Regulation Of Cytoskeleton Organization Microtubule-based Process Centriole Replication Regulation Of Centriole Replication Regulation Of Protein Localization To Synapse Nuclear Pore Localization Regulation Of Receptor Localization To Synapse Centriole Assembly Negative Regulation Of Microtubule Depolymerization Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Activity Microtubule Organizing Center Organization Negative Regulation Of Supramolecular Fiber Organization Protein Ubiquitination Negative Regulation Of Centriole Replication Regulation Of Microtubule Depolymerization Cytoplasm Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Centrosome Duplication Protein Binding Negative Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Protein Localization To Microtubule Cytoskeleton XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cul5-RING Ubiquitin Ligase Complex Regulation Of RNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?