AK1 and TERF2IP

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		AK1	TERF2IP
Gene Name		adenylate kinase 1	telomeric repeat binding factor 2, interacting protein
Image
Gene Ontology Annotations	Cellular Component	Outer Dense Fiber Cytoplasm Cytosol Plasma Membrane Sperm Flagellum Extracellular Vesicular Exosome	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex
	Molecular Function	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding	Protein Binding Telomeric DNA Binding
	Biological Process	Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Cell Cycle Arrest Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process AMP Metabolic Process ATP Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs		Bis(Adenosine)-5\'-Pentaphosphate
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP FHL2 TERF1 TERF2IP TINF2 TRIM63	125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414
Entrez ID		203	54386
HPRD ID		00046	05452
Ensembl ID		ENSG00000106992	ENSG00000166848
Uniprot IDs		P00568 Q5T9B7 Q6FGX9	Q9NYB0
PDB IDs		1Z83 2C95	1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Regulation Of Chromosome Organization Protein Localization To Chromosome Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Collateral Sprouting In Absence Of Injury Telomeric Loop Formation Age-dependent Telomere Shortening Atrial Cardiac Muscle Cell Development Negative Regulation Of Cellular Protein Metabolic Process Telomere Maintenance Via Telomere Shortening Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Protein Glycosylation Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Organelle Organization Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Skeletal Muscle Atrophy Chromosome Organization DNA Metabolic Process Axon Choice Point Recognition Striated Muscle Atrophy Telomere Assembly	Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds
Tagcloud ?		aids biosynthesis cdk5r2 cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Difference) ?		aids biosynthesis cdk5r2 cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Intersection) ?