AK1 and TINF2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		AK1	TINF2
Gene Name		adenylate kinase 1	TERF1 (TRF1)-interacting nuclear factor 2
Image
Gene Ontology Annotations	Cellular Component	Outer Dense Fiber Cytoplasm Cytosol Plasma Membrane Sperm Flagellum Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Cell Cycle Arrest Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process AMP Metabolic Process ATP Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs		Bis(Adenosine)-5\'-Pentaphosphate
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP FHL2 TERF1 TERF2IP TINF2 TRIM63	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		203	26277
HPRD ID		00046	16056
Ensembl ID		ENSG00000106992	ENSG00000092330
Uniprot IDs		P00568 Q5T9B7 Q6FGX9	B4DFJ1 Q9BSI4
PDB IDs		1Z83 2C95	3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Regulation Of Chromosome Organization Protein Localization To Chromosome Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Collateral Sprouting In Absence Of Injury Telomeric Loop Formation Age-dependent Telomere Shortening Atrial Cardiac Muscle Cell Development Negative Regulation Of Cellular Protein Metabolic Process Telomere Maintenance Via Telomere Shortening Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Protein Glycosylation Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Organelle Organization Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Skeletal Muscle Atrophy Chromosome Organization DNA Metabolic Process Axon Choice Point Recognition Striated Muscle Atrophy Telomere Assembly	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?		aids biosynthesis cdk5r2 cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		aids biosynthesis cdk5r2 cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?