FEN1 and EEF1G

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		FEN1	EEF1G
Description		flap structure-specific endonuclease 1	eukaryotic translation elongation factor 1 gamma
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Protein-containing Complex	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity Manganese Ion Binding Metal Ion Binding Flap Endonuclease Activity	Translation Elongation Factor Activity Protein Binding Cadherin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Double-strand Break Repair DNA Recombination DNA Damage Response Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Positive Regulation Of Sister Chromatid Cohesion	Translation Translational Elongation Response To Virus
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate	Eukaryotic Translation Elongation Signaling by ALK fusions and activated point mutants
Drugs		Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Asthma ( 31619474 31959851) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 28067908) Daytime nap ( 33568662) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hemoglobin levels ( 32327693) Laryngeal squamous cell carcinoma ( 25194280) Male-pattern baldness ( 28196072) Metabolite levels ( 23378610 23823483) Oleic acid (18:1n-9) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 22139419) QT interval ( 29874175) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278) Resting heart rate ( 27798624) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Stearic acid (18:0) levels ( 23362303)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		20 interacting genes: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 CEBPA EEF1G EP300 GSK3B HNRNPA1 HUS1 OGT PCNA RAD1 RAD9A TERF1 WDR4 WRN	100 interacting genes: ABCC9 ADAP2 AKT1 ANKRD28 ARF1 ARIH2 C11orf58 C1orf174 CARS1 CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CEBPA CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DLG4 DRD3 DYSF ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EID2B EIF4ENIF1 ENOX1 FAM200C FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS1 HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS1 KLHL18 LARS1 LINC01554 LZTS1 MBD1 MCRIP2 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 OGT PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRF PTPRS RBM6 RECQL5 RGL2 RNF26 RPL4P5 RPS28 SAT1 SFRP2 SKIL SLC22A2 SNAPIN SNRPD2 SUMO2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 USP7 WDR33 YWHAG ZDHHC17 ZNF24
Entrez ID		2237	1937
HPRD ID		02670	11745
Ensembl ID		ENSG00000168496	ENSG00000254772
Uniprot IDs		P39748 Q6FHX6	P26641 Q53YD7
PDB IDs		1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7 5K97 5KSE 5UM9 5ZOD 5ZOE 5ZOF 5ZOG 6TNZ 7QO1 8YJH 8YJL 8YJQ 8YJR 8YJS 8YJU 8YJV 8YJW 8YJZ	1PBU 5DQS 5JPO
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Telomere Maintenance Telomere Organization Nucleic Acid Metabolic Process DNA Damage Response Response To Stress Macromolecule Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Chromosome Organization Nucleus DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Intracellular Signal Transduction Nucleoplasm Mitotic DNA Damage Checkpoint Signaling Checkpoint Clamp Complex Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-stranded DNA 3'-5' DNA Exonuclease Activity Regulation Of DNA Metabolic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Cell Cycle Telomeric D-loop Disassembly Negative Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of DNA Replication Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Telomeric Loop Disassembly T-circle Formation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Macromolecule Metabolic Process Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA Replication 3'-5' Exonuclease Activity Damaged DNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Translation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Protein Catabolic Process Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Neuron Projection Organization MRNA Cleavage And Polyadenylation Specificity Factor Complex TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Cell Adhesion Mediated By Integrin Regulation Of TORC1 Signaling Regulation Of TOR Signaling Regulation Of Cellular Component Organization Response To Stress Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Kinase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Developmental Process Hematopoietic Stem Cell Proliferation Protein Metabolic Process Potassium Channel Activator Activity RNA Metabolic Process Glutamatergic Synapse Negative Regulation Of Proteasomal Protein Catabolic Process PML Body Phosphatidylinositol-3,4-bisphosphate Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Positive Regulation Of TORC1 Signaling Regulation Of Chromosome Organization Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Protein Modification By Small Protein Conjugation
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