FEN1 and CCNA2

Number of citations of the paper that reports this interaction (PMID 12853968)
23

Data Source:
BioGRID (enzymatic study, pull down, affinity chromatography technology)

		FEN1	CCNA2
Gene Name		flap structure-specific endonuclease 1	cyclin A2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Plasma Membrane Membrane	Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Manganese Ion Binding	Protein Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Estradiol Response To Glucagon Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Cell Division
Pathways		Base Excision Repair Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere Extension of Telomeres S Phase Telomere C-strand (Lagging Strand) Synthesis DNA strand elongation Cell Cycle, Mitotic Removal of the Flap Intermediate Telomere Maintenance Resolution of AP sites via the multiple-nucleotide patch replacement pathway Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand	Cellular Senescence G2/M Transition Orc1 removal from chromatin Cyclin E associated events during G1/S transition Cyclin A/B1 associated events during G2/M transition G1/S Transition G2 Phase Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Orc1 removal from chromatin SCF(Skp2)-mediated degradation of p27/p21 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases
Drugs
Diseases
GWAS		Metabolite levels ( 23378610) Oleic acid (18:1n-9) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377) Platelet counts ( 22139419) Stearic acid (18:0) plasma levels ( 23362303)
Protein-Protein Interactions		15 interactors: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 EEF1G EP300 GSK3B HNRNPA1 PCNA RAD1 TERF1 WRN	50 interactors: ARID4A BRCA1 BRCA2 BTG1 CALM1 CDC20 CDC25C CDC27 CDC6 CDK1 CDK2 CDK3 CDK7 CDKN1A CDKN1B CDT1 CKS1B CKS1BP7 CKS2 DTNBP1 E2F1 E2F3 FEN1 FZR1 HERC5 HIRA HIST1H1A HIST1H1B ITGB3BP KAT2B MYBL2 NFYA PGR POLA1 PRC1 PSMD4 PTMA RAD23A RB1 RBL1 RBL2 RPA1 SKP1 SKP2 SP1 TAF1 TP53 TRAF3IP1 UBTF USP37
Entrez ID		2237	890
HPRD ID		02670	00453
Ensembl ID		ENSG00000168496	ENSG00000145386
Uniprot IDs		P39748 Q6FHX6	P20248
PDB IDs		1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3
Enriched GO Terms of Interacting Partners?		DNA Replication Cell Cycle Process Cellular Response To DNA Damage Stimulus Cell Cycle Regulation Of Cell Cycle Telomere Maintenance Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cell Cycle Checkpoint Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Replication DNA Damage Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Chromosome Organization DNA Metabolic Process Mitotic Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Response To Inorganic Substance Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Metabolic Process Response To Stress DNA-dependent DNA Replication Positive Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stimulus Response To Oxidative Stress Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Ionizing Radiation Regulation Of Cellular Protein Metabolic Process	Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cell Cycle Checkpoint Cell Division Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Chromatin Organization Regulation Of Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Positive Regulation Of Gene Expression Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Proteasomal Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Chromatin Modification DNA Replication Positive Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Heterocycle Metabolic Process
Tagcloud ?		alka alphaherpesvirus analogy backbone cnjb complexed contrasts crystallographic emb endonuclease helical helix hhh kinesin kraut kumar motifs nitrogens nuclease pelletier pol primer sawaya searches shutoff spt6 taq virion wilson	calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		alka alphaherpesvirus analogy backbone cnjb complexed contrasts crystallographic emb endonuclease helical helix hhh kinesin kraut kumar motifs nitrogens nuclease pelletier pol primer sawaya searches shutoff spt6 taq virion wilson	calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?