FEN1 and ARHGDIA

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		FEN1	ARHGDIA
Gene Name		flap structure-specific endonuclease 1	Rho GDP dissociation inhibitor (GDI) alpha
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Plasma Membrane Membrane	Immunological Synapse Cytosol Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Manganese Ion Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Cell Migration Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway
Pathways		Base Excision Repair Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere Extension of Telomeres S Phase Telomere C-strand (Lagging Strand) Synthesis DNA strand elongation Cell Cycle, Mitotic Removal of the Flap Intermediate Telomere Maintenance Resolution of AP sites via the multiple-nucleotide patch replacement pathway Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand	Rho GTPase cycle Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis Axonal growth stimulation Signaling by Rho GTPases p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Metabolite levels ( 23378610) Oleic acid (18:1n-9) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377) Platelet counts ( 22139419) Stearic acid (18:0) plasma levels ( 23362303)
Protein-Protein Interactions		15 interactors: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 EEF1G EP300 GSK3B HNRNPA1 PCNA RAD1 TERF1 WRN	36 interactors: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B FEN1 HAAO HERPUD1 IKBKG JUP MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		2237	396
HPRD ID		02670	03565
Ensembl ID		ENSG00000168496	ENSG00000141522
Uniprot IDs		P39748 Q6FHX6	J3QQX2 J3QW41 P52565
PDB IDs		1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0
Enriched GO Terms of Interacting Partners?		DNA Replication Cell Cycle Process Cellular Response To DNA Damage Stimulus Cell Cycle Regulation Of Cell Cycle Telomere Maintenance Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cell Cycle Checkpoint Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Replication DNA Damage Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Chromosome Organization DNA Metabolic Process Mitotic Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Response To Inorganic Substance Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Metabolic Process Response To Stress DNA-dependent DNA Replication Positive Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stimulus Response To Oxidative Stress Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Ionizing Radiation Regulation Of Cellular Protein Metabolic Process	Response To Stress Response To Stimulus Cellular Response To Stimulus Homeostatic Process Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction Positive Regulation Of Cell Death Signaling Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Component Biogenesis Cell Communication Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Projection Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Catalytic Activity Regulation Of DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Programmed Cell Death Small GTPase Mediated Signal Transduction Blood Coagulation Regulation Of Telomere Maintenance Hemostasis Response To Abiotic Stimulus Regulation Of Signaling Telomere Maintenance Regulation Of Catalytic Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Lamellipodium Assembly Response To Wounding Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Organic Substance
Tagcloud ?		alka alphaherpesvirus analogy backbone cnjb complexed contrasts crystallographic emb endonuclease helical helix hhh kinesin kraut kumar motifs nitrogens nuclease pelletier pol primer sawaya searches shutoff spt6 taq virion wilson	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Difference) ?		alka alphaherpesvirus analogy backbone cnjb complexed contrasts crystallographic emb endonuclease helical helix hhh kinesin kraut kumar motifs nitrogens nuclease pelletier pol primer sawaya searches shutoff spt6 taq virion wilson	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Intersection) ?