PDZRN3 and SLC5A8

Number of citations of the paper that reports this interaction (PubMedID 31098988)
25

Data Source:
BioGRID (two hybrid)

		PDZRN3	SLC5A8
Description		PDZ domain containing ring finger 3	solute carrier family 5 member 8
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GO Annotations	Cellular Component	Cytoplasm Neuromuscular Junction Synapse	GINS Complex Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Organic Acid:sodium Symporter Activity Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Propionate Transmembrane Transporter Activity Short-chain Fatty Acid Transmembrane Transporter Activity Transmembrane Transporter Activity Monocarboxylate:sodium Symporter Activity Iodide Channel Activity
	Biological Process	Neuromuscular Junction Development Protein Ubiquitination	Monoatomic Ion Transport Sodium Ion Transport Chloride Transport Acetate Transport Pyruvate Transport Apoptotic Process Iodide Transport Nitrate Transmembrane Transport Monocarboxylic Acid Transport Lactate Transport Propanoate Transmembrane Transport Short-chain Fatty Acid Transmembrane Transport NAD+ Biosynthetic Process Via The Salvage Pathway Sodium Ion Transmembrane Transport Lactate Transmembrane Transport Transmembrane Transport Nicotinate Transport
Pathways			Nicotinate metabolism Organic anion transport by SLC5/17/25 transporters SLC-mediated transport of inorganic anions
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Mercury levels ( 26025379) Mitochondrial DNA copy number (white blood cells) ( 30704525) PR interval ( 30046033 30679814 32439900)	A body shape index ( 34021172) Amyotrophic lateral sclerosis (sporadic) ( 24529757) California verbal learning test score ( 31596458) Waist-hip index ( 34021172)
Interacting Genes		8 interacting genes: BMPR2 EFNB2 LNX1 LNX2 RPS6KA1 SLC5A8 UBE2D2 VANGL2	1 interacting genes: PDZRN3
Entrez ID		23024	160728
HPRD ID		15115	10475
Ensembl ID		ENSG00000121440	ENSG00000256870
Uniprot IDs		B7Z2I8 B7Z5Q3 B7Z5X9 B7ZAG0 E7ENB6 Q9UPQ7	Q8N695
PDB IDs		1UHP 1WH1	7SL9
Enriched GO Terms of Interacting Partners?		Epithelial Cell Proliferation Tube Morphogenesis Blood Vessel Morphogenesis Apical Plasma Membrane Animal Organ Morphogenesis Proteoglycan Metabolic Process System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Activin Receptor Activity, Type II Cell Population Proliferation Proteoglycan Biosynthetic Process Epithelial Tube Morphogenesis Postsynaptic Density Membrane Positive Regulation Of Aorta Morphogenesis Ubiquitin-protein Transferase Activity Serotonergic Neuron Axon Guidance Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis PDZ Domain Binding Acetate Transport Monocarboxylate:sodium Symporter Activity Short-chain Fatty Acid Transmembrane Transport Organic Acid:sodium Symporter Activity Nitrate Transmembrane Transport Propanoate Transmembrane Transport Short-chain Fatty Acid Transport Propionate Transmembrane Transporter Activity Short-chain Fatty Acid Transmembrane Transporter Activity Nicotinate Transport Iodide Channel Activity Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Aorta Morphogenesis Nervous System Development Apical Cytoplasm Establishment Of Body Hair Planar Orientation Anterior/posterior Pattern Specification Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation
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