MECOM and MBD3

Number of citations of the paper that reports this interaction (PMID 18500823)
5

Data Source:
BioGRID (pull down)

		MECOM	MBD3
Gene Name		MDS1 and EVI1 complex locus	methyl-CpG binding domain protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Aggresome Nuclear Speck Intracellular Membrane-bounded Organelle	Nuclear Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	In Utero Embryonic Development Neutrophil Homeostasis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Inflammatory Response Response To Bacterium Post-embryonic Development Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Development Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Regulation Of Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Pericardium Development Hematopoietic Stem Cell Proliferation Renal System Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Methylation-dependent Chromatin Silencing Transcription, DNA-templated Tissue Development Histone Acetylation ATP-dependent Chromatin Remodeling
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS		Aging (time to event) ( 21782286) Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Osteoporosis ( 23349225) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		13 interactors: CREBBP CTBP1 CTBP2 HDAC1 HDAC4 KAT2B MBD3 PRMT1 SMAD1 SMAD2 SMAD3 SMAD4 SUMO1	28 interactors: AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 HDAC1 HIST3H3 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA1 MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZNF277
Entrez ID		2122	53615
HPRD ID		01310	04653
Ensembl ID		ENSG00000085276	ENSG00000071655
Uniprot IDs		C7FEN9 E7EQ57 Q03112 Q13465	O95983
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression SMAD Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation Regulation Of RNA Metabolic Process Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Primary MiRNA Processing Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Embryo Development Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Pattern Specification Cellular Nitrogen Compound Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptidyl-lysine Modification	ATP-dependent Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Chromatin Organization Transcription, DNA-templated Chromosome Organization Chromatin Modification RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Remodeling RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification Histone Modification Negative Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Interaction With Symbiont Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3-K4 Demethylation Chromatin Assembly Or Disassembly Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Binding
Tagcloud ?		admitted aggressive aml april attributed august d816v documentation eosinophilia homogeneous hypothesized infarction initially kit ldh leukemic man minor myeloproliferative myocardial neoplasm novo occurrence persisting runx1 splenomegaly thalassemia unrecognized v617f	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Difference) ?		admitted aggressive aml april attributed august d816v documentation eosinophilia homogeneous hypothesized infarction initially kit ldh leukemic man minor myeloproliferative myocardial neoplasm novo occurrence persisting runx1 splenomegaly thalassemia unrecognized v617f	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Intersection) ?