MECOM and PPP1R9A

Number of citations of the paper that reports this interaction (PubMedID 23858473)
53

Data Source:
BioGRID (two hybrid)

		MECOM	PPP1R9A
Description		MDS1 and EVI1 complex locus	protein phosphatase 1 regulatory subunit 9A
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Cytoplasm Cytoskeleton Postsynaptic Density Actin Cytoskeleton Filopodium Dendrite Cortical Actin Cytoskeleton Neuron Projection Dendritic Spine Synapse Plasma Membrane Bounded Cell Projection
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Methylation Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation	Actin Filament Organization Nervous System Development Calcium-mediated Signaling Cell Differentiation Neuron Projection Development Modulation Of Chemical Synaptic Transmission
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription Formation of the nephric duct
Drugs
Diseases		Chronic myeloid leukemia (CML)
GWAS		Aging (time to event) ( 21782286) Appendicular lean mass ( 33097823) Asthma ( 32296059) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 29403010 31152163) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Calcific aortic valve stenosis ( 32141789) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27618452 27841878 32902719 21909115 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate ( 29403010) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hematocrit ( 32888494 27863252) Hematology traits ( 30576415) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31959993 29617998 29785010) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200 25849990) Nasopharyngeal carcinoma ( 26545403) Neonatal white matter microstructure ( 33009551) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252 32888494) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 27618452 27618447 21909115 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528) Weight ( 34074324) White blood cell count ( 32888494)	Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Waist circumference ( 28552196)
Interacting Genes		63 interacting genes: ANKRD11 ARHGEF37 BAG6 BRD2 CAGE1 CAVIN1 CCDC180 CEP128 CHERP CLIC3 CREBBP CSNK2A1 CTBP1 CTBP2 DZIP1 EPB41L3 GAS7 GOLGA6L1 GTF3C2 HDAC1 HDAC4 HIC1 HSF2 HSF2BP JUN KAT2B KNSTRN LNX2 MAGI3 MBD3 NIBAN2 NMRAL1 OIP5 PACSIN2 PCBP2 PIK3R3 PKM PLXNB1 PPP1CA PPP1R9A PPP1R9B PRMT1 RB1CC1 RBM11 RNF31 SF3B1 SMAD1 SMAD2 SMAD3 SMAD4 SNX9 SOX13 SREBF1 TLE5 TPR TRIM11 TRIM26 TRIM58 TSNAX UBAC1 UBE2I VPS39 ZC4H2	11 interacting genes: ACTG1 MECOM PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9B PRKAR1B RPS6KA1 RPS6KB1 TGOLN2
Entrez ID		2122	55607
HPRD ID		01310	16000
Ensembl ID		ENSG00000085276	ENSG00000158528
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112	A4D1I0 B7ZLX4 Q9ULJ8
PDB IDs		6BW3	1WF8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Negative Regulation Of Biosynthetic Process Chromatin I-SMAD Binding DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Binding Chromatin Binding Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Developmental Process Negative Regulation Of Metabolic Process R-SMAD Binding Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Endoderm Development Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Co-SMAD Binding Peptidyl-lysine Acetylation Primary MiRNA Processing Homomeric SMAD Protein Complex Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Transcription Coregulator Binding	PTW/PP1 Phosphatase Complex Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Energy Derivation By Oxidation Of Organic Compounds Circadian Regulation Of Gene Expression Phosphatase Activity Glutamatergic Synapse Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Phosphatase Type 1 Complex Generation Of Precursor Metabolites And Energy Regulation Of Circadian Rhythm Dephosphorylation Circadian Rhythm Carbohydrate Metabolic Process Regulation Of Translation In Response To Stress Phosphoprotein Phosphatase Activity Dendritic Spine Protein Serine/threonine/tyrosine Kinase Activity Synapse Chromosome, Telomeric Region Postsynapse Intracellular Signal Transduction Protein Phosphatase Inhibitor Activity Rhythmic Process Basal Body Patch Nucleoplasm Myosin-light-chain-phosphatase Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane TORC1 Signaling Cellular Response To Type II Interferon Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Response To Light Stimulus Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity TOR Signaling Negative Regulation Of TOR Signaling Intracellular Signaling Cassette Schaffer Collateral - CA1 Synapse Response To Type II Interferon Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
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