MECOM and NMRAL1

Number of citations of the paper that reports this interaction (PubMedID 23858473)
53

Data Source:
BioGRID (two hybrid)

		MECOM	NMRAL1
Description		MDS1 and EVI1 complex locus	NmrA like redox sensor 1
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity	Protein Binding Identical Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Methylation Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription Formation of the nephric duct	Urea cycle
Drugs			2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID
Diseases		Chronic myeloid leukemia (CML)
GWAS		Aging (time to event) ( 21782286) Appendicular lean mass ( 33097823) Asthma ( 32296059) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 29403010 31152163) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Calcific aortic valve stenosis ( 32141789) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27618452 27841878 32902719 21909115 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate ( 29403010) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hematocrit ( 32888494 27863252) Hematology traits ( 30576415) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31959993 29617998 29785010) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200 25849990) Nasopharyngeal carcinoma ( 26545403) Neonatal white matter microstructure ( 33009551) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252 32888494) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 27618452 27618447 21909115 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528) Weight ( 34074324) White blood cell count ( 32888494)	Erectile dysfunction ( 30583798) Schizophrenia ( 28991256) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		63 interacting genes: ANKRD11 ARHGEF37 BAG6 BRD2 CAGE1 CAVIN1 CCDC180 CEP128 CHERP CLIC3 CREBBP CSNK2A1 CTBP1 CTBP2 DZIP1 EPB41L3 GAS7 GOLGA6L1 GTF3C2 HDAC1 HDAC4 HIC1 HSF2 HSF2BP JUN KAT2B KNSTRN LNX2 MAGI3 MBD3 NIBAN2 NMRAL1 OIP5 PACSIN2 PCBP2 PIK3R3 PKM PLXNB1 PPP1CA PPP1R9A PPP1R9B PRMT1 RB1CC1 RBM11 RNF31 SF3B1 SMAD1 SMAD2 SMAD3 SMAD4 SNX9 SOX13 SREBF1 TLE5 TPR TRIM11 TRIM26 TRIM58 TSNAX UBAC1 UBE2I VPS39 ZC4H2	5 interacting genes: FOXJ1 MECOM PCNA USP1 WDR48
Entrez ID		2122	57407
HPRD ID		01310	13678
Ensembl ID		ENSG00000085276	ENSG00000153406
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112	A0A384P622 Q9HBL8
PDB IDs		6BW3	2EXX 2WM3 2WMD 3DXF 3E5M
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Negative Regulation Of Biosynthetic Process Chromatin I-SMAD Binding DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Binding Chromatin Binding Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Developmental Process Negative Regulation Of Metabolic Process R-SMAD Binding Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Endoderm Development Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Co-SMAD Binding Peptidyl-lysine Acetylation Primary MiRNA Processing Homomeric SMAD Protein Complex Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Transcription Coregulator Binding	Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Macromolecule Metabolic Process Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of DNA Metabolic Process PCNA Complex Regulation Of Cellular Response To Stress Replisome DNA Repair Regulation Of DNA Biosynthetic Process Positive Regulation Of Error-prone Translesion Synthesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Metabolic Process Response To UV Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding DNA Damage Response DNA Binding Metanephric Part Of Ureteric Bud Development Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Ciliary Basal Body Organization Tube Development Histone H3K9 Monomethyltransferase Activity Regulation Of Protein Monoubiquitination Regulation Of Primary Metabolic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Deubiquitinase Activator Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K9me2 Methyltransferase Activity Developmental Process Regulation Of Germinal Center Formation
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