MECOM and KNSTRN

Number of citations of the paper that reports this interaction (PubMedID 23858473)
53

Data Source:
BioGRID (two hybrid)

		MECOM	KNSTRN
Description		MDS1 and EVI1 complex locus	kinetochore localized astrin (SPAG5) binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Chromosome, Centromeric Region Kinetochore Spindle Pole Ruffle Nucleus Chromosome Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Plasma Membrane Centriolar Satellite Microtubule Plus-end Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity	Protein Binding Protein Homodimerization Activity Microtubule Plus-end Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Methylation Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Spindle Organization Chromosome Segregation Cell Migration Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Epidermal Growth Factor Stimulus
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription Formation of the nephric duct
Drugs
Diseases		Chronic myeloid leukemia (CML)
GWAS		Aging (time to event) ( 21782286) Appendicular lean mass ( 33097823) Asthma ( 32296059) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 29403010 31152163) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Calcific aortic valve stenosis ( 32141789) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27618452 27841878 32902719 21909115 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate ( 29403010) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hematocrit ( 32888494 27863252) Hematology traits ( 30576415) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31959993 29617998 29785010) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200 25849990) Nasopharyngeal carcinoma ( 26545403) Neonatal white matter microstructure ( 33009551) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252 32888494) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 27618452 27618447 21909115 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528) Weight ( 34074324) White blood cell count ( 32888494)	Heschl's gyrus morphology ( 25130324) Malaria ( 31844061)
Interacting Genes		63 interacting genes: ANKRD11 ARHGEF37 BAG6 BRD2 CAGE1 CAVIN1 CCDC180 CEP128 CHERP CLIC3 CREBBP CSNK2A1 CTBP1 CTBP2 DZIP1 EPB41L3 GAS7 GOLGA6L1 GTF3C2 HDAC1 HDAC4 HIC1 HSF2 HSF2BP JUN KAT2B KNSTRN LNX2 MAGI3 MBD3 NIBAN2 NMRAL1 OIP5 PACSIN2 PCBP2 PIK3R3 PKM PLXNB1 PPP1CA PPP1R9A PPP1R9B PRMT1 RB1CC1 RBM11 RNF31 SF3B1 SMAD1 SMAD2 SMAD3 SMAD4 SNX9 SOX13 SREBF1 TLE5 TPR TRIM11 TRIM26 TRIM58 TSNAX UBAC1 UBE2I VPS39 ZC4H2	17 interacting genes: ABI2 BEX2 CHMP1B CLU HSPB1 IFT20 MAPK6 MAPRE1 MAPRE3 MECOM MPHOSPH6 NUPR1 OIP5 PALS2 PPL WASHC3 ZDHHC17
Entrez ID		2122	90417
HPRD ID		01310	12669
Ensembl ID		ENSG00000085276	ENSG00000128944
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112	Q9Y448
PDB IDs		6BW3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Negative Regulation Of Biosynthetic Process Chromatin I-SMAD Binding DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Binding Chromatin Binding Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Developmental Process Negative Regulation Of Metabolic Process R-SMAD Binding Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Endoderm Development Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Co-SMAD Binding Peptidyl-lysine Acetylation Primary MiRNA Processing Homomeric SMAD Protein Complex Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Transcription Coregulator Binding	Mitotic Spindle Astral Microtubule End Regulation Of Organelle Organization Regulation Of Supramolecular Fiber Organization Intracellular Protein Localization Cellular Component Assembly Regulation Of Cytoskeleton Organization Protein Localization To Microtubule Microtubule Plus-end Binding Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Binding Microtubule Plus-end Cytoskeleton Spindle Midzone Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Transport Regulation Of Actin Nucleation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Perinuclear Endoplasmic Reticulum Lumen Establishment Of Protein Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Negative Regulation Of Protein Kinase C Signaling Identical Protein Binding Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cell Division Protein Localization To Astral Microtubule Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Autophagosome Assembly Protein Localization To Cytoskeleton Regulation Of Dendritic Spine Development Positive Regulation Of Cellular Component Biogenesis Cornified Envelope Cytoplasmic Microtubule Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein-containing Complex Organization Septin Cytoskeleton Actin Polymerization Or Depolymerization Zonula Adherens Assembly Protein Localization To Mitotic Spindle Regulation Of Microtubule Polymerization Protein Localization To Spindle Microtubule Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Vacuole Organization Regulation Of Organelle Assembly Opsin Transport Intraciliary Transport Particle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?