MBD3 and AGR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MBD3	AGR2
Description		methyl-CpG binding domain protein 3	anterior gradient 2, protein disulphide isomerase family member
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1
Entrez ID		53615	10551
HPRD ID		04653	05896
Ensembl ID		ENSG00000071655	ENSG00000106541
Uniprot IDs		O95983	O95994 Q4JM46
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	2LNS 2LNT
Enriched GO Terms of Interacting Partners?		NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification	Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway
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