MBD3 and ERCC6

Number of citations of the paper that reports this interaction (PubMedID 31722399)
57

Data Source:
BioGRID (pull down)

		MBD3	ERCC6
Description		methyl-CpG binding domain protein 3	ERCC excision repair 6, chromatin remodeling factor
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Chromosome Nucleolus Transcription Elongation Factor Complex Nuclear Body Site Of DNA Damage B-WICH Complex
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Nucleotide Binding DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding RNA Polymerase Binding Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Positive Regulation Of Defense Response To Virus By Host DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II DNA Damage Response Response To Oxidative Stress JNK Cascade Nervous System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Positive Regulation Of Gene Expression Protein Ubiquitination Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Transcription Elongation By RNA Polymerase II Multicellular Organism Growth DNA Protection Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription Initiation By RNA Polymerase II Protein Localization To Chromatin Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 DCLRE1A ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38
Entrez ID		53615	2074
HPRD ID		04653	00596
Ensembl ID		ENSG00000071655	ENSG00000225830
Uniprot IDs		O95983	P0DP91 Q03468 Q59FF6
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	4CVO 6A6I 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification	Translation Ribosome Macromolecule Metabolic Process RNA Binding Macromolecule Biosynthetic Process Structural Constituent Of Ribosome Ribonucleoprotein Complex Mitochondrial Translation Nucleoplasm Protein Metabolic Process NuRD Complex Mitochondrial Large Ribosomal Subunit Mitochondrial Inner Membrane Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Nucleus Protein-RNA Complex Assembly Cytosolic Ribosome Ubiquitin Protein Ligase Binding Nucleic Acid Metabolic Process PML Body Regulation Of Stem Cell Differentiation Small Protein Activating Enzyme Binding Cytoplasmic Translation Formation Of Cytoplasmic Translation Initiation Complex Chromosome, Telomeric Region Eukaryotic Translation Initiation Factor 3 Complex Nucleobase-containing Compound Metabolic Process Eukaryotic 48S Preinitiation Complex Protein Sumoylation Mitochondrion Eukaryotic 43S Preinitiation Complex Cytoplasmic Translational Initiation Chromatin Organization Protein-containing Complex Nucleosomal DNA Binding Nucleolus DNA Repair Chromatin Remodeling Mitochondrial Ribosome Regulation Of Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Translational Initiation Nucleotide-excision Repair Protein-containing Complex Organization DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein-containing Complex Assembly Chromosome
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