MBD3 and GADD45GIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MBD3	GADD45GIP1
Description		methyl-CpG binding domain protein 3	GADD45G interacting protein 1
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation	Mitochondrial Translation
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS			Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	62 interacting genes: ANKRD28 APP AR BPIFA1 CADPS CARD10 CBY2 CCNC CEP70 CSNK2B DRC4 DVL3 EAF1 ENKD1 EXOSC4 FBXO7 GADD45A GADD45B GADD45G GEM GOLGA2 GOLGA6A GOLGA6L9 GPRASP2 HMG20A IKBKG KANK2 KIFC3 KRT27 KRT31 KRT34 KRT40 LDOC1 LRRC73 LZTS2 MAGEA11 MAGEA6 MBD3 MIPOL1 MKRN3 MTUS2 MYG1 MYO15B NFKBID NR4A1 NTAQ1 NUTM1 OIP5 PBX4 PICK1 PNMA1 PRDM6 PSMB1 RBM11 SPTA1 TFIP11 TRAF1 TRIM27 UBC UPF2 WWP2 ZRANB1
Entrez ID		53615	90480
HPRD ID		04653	05519
Ensembl ID		ENSG00000071655	ENSG00000179271
Uniprot IDs		O95983	Q8TAE8
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OI6 7OI7 7OI8 7OI9 7OIA 7OIB 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIT 8PK0 8QSJ 8QU5 8RRI 8XT0 8XT1 8XT2 8XT3
Enriched GO Terms of Interacting Partners?		NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification	Protein Binding Positive Regulation Of JNK Cascade Nucleus Structural Constituent Of Skin Epidermis Identical Protein Binding Positive Regulation Of P38MAPK Cascade Intermediate Filament Organization Regulation Of JNK Cascade
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