MBD3 and ATF7

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		MBD3	ATF7
Description		methyl-CpG binding domain protein 3	activating transcription factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding CAMP Response Element Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs			Pseudoephedrine
Diseases
GWAS			Basophil count ( 32888494) Electroencephalogram traits ( 25387704) Heel bone mineral density ( 30598549) Height ( 20189936 21998595 25429064 31562340) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	18 interacting genes: ATF2 FAM9B FCER2 FOS KASH5 MAPK9 MBD3 MITD1 OCIAD1 PTP4A1 PTP4A2 TAF12 TAF4 TAOK3 TMEM239 UBC URI1 YY1
Entrez ID		53615	11016
HPRD ID		04653	06968
Ensembl ID		ENSG00000071655	ENSG00000170653
Uniprot IDs		O95983	P17544
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?		NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification	MRNA Transcription By RNA Polymerase II MRNA Transcription DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Abducens Nucleus Development Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Chromatin Binding Nucleoplasm Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Promoter-specific Chromatin Binding DNA Damage Response Hypoglossal Nucleus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process JNK Cascade Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Stress H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Transcription By RNA Polymerase II Cellular Response To Chemical Stress Growth Plate Cartilage Chondrocyte Proliferation Positive Regulation Of RNA Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process MAPK Cascade B Cell Antigen Processing And Presentation Fc Receptor Signaling Pathway Low-affinity IgE Receptor Activity Fc Receptor-mediated Immune Complex Endocytosis Fc-epsilon Receptor Signaling Pathway Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Transcription Medium-term Memory Cellular Response To Prolactin JUN Kinase Activity Protein Localization To Tricellular Tight Junction Regulation Of Cellular Response To Stress Transcription Factor TFTC Complex Transcription Factor TFIID Complex Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation
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