MECOM and PLXNB1

Number of citations of the paper that reports this interaction (PubMedID 23858473)
53

Data Source:
BioGRID (two hybrid)

		MECOM	PLXNB1
Description		MDS1 and EVI1 complex locus	plexin B1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Methylation Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation	Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Semaphorin-plexin Signaling Pathway Inhibitory Synapse Assembly
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription Formation of the nephric duct	G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RHOD GTPase cycle
Drugs
Diseases		Chronic myeloid leukemia (CML)
GWAS		Aging (time to event) ( 21782286) Appendicular lean mass ( 33097823) Asthma ( 32296059) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 29403010 31152163) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Calcific aortic valve stenosis ( 32141789) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27618452 27841878 32902719 21909115 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate ( 29403010) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hematocrit ( 32888494 27863252) Hematology traits ( 30576415) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31959993 29617998 29785010) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200 25849990) Nasopharyngeal carcinoma ( 26545403) Neonatal white matter microstructure ( 33009551) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252 32888494) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 27618452 27618447 21909115 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528) Weight ( 34074324) White blood cell count ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		63 interacting genes: ANKRD11 ARHGEF37 BAG6 BRD2 CAGE1 CAVIN1 CCDC180 CEP128 CHERP CLIC3 CREBBP CSNK2A1 CTBP1 CTBP2 DZIP1 EPB41L3 GAS7 GOLGA6L1 GTF3C2 HDAC1 HDAC4 HIC1 HSF2 HSF2BP JUN KAT2B KNSTRN LNX2 MAGI3 MBD3 NIBAN2 NMRAL1 OIP5 PACSIN2 PCBP2 PIK3R3 PKM PLXNB1 PPP1CA PPP1R9A PPP1R9B PRMT1 RB1CC1 RBM11 RNF31 SF3B1 SMAD1 SMAD2 SMAD3 SMAD4 SNX9 SOX13 SREBF1 TLE5 TPR TRIM11 TRIM26 TRIM58 TSNAX UBAC1 UBE2I VPS39 ZC4H2	15 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MECOM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4
Entrez ID		2122	5364
HPRD ID		01310	03032
Ensembl ID		ENSG00000085276	ENSG00000164050
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112	O43157
PDB IDs		6BW3	2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W 7VF3 7VG7 8B3K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Negative Regulation Of Biosynthetic Process Chromatin I-SMAD Binding DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Binding Chromatin Binding Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Developmental Process Negative Regulation Of Metabolic Process R-SMAD Binding Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Endoderm Development Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Co-SMAD Binding Peptidyl-lysine Acetylation Primary MiRNA Processing Homomeric SMAD Protein Complex Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Transcription Coregulator Binding	Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Chemotaxis Locomotion Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Hypothalamus Cell Migration Neuron Projection Development Neural Crest Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Mesenchymal Cell Migration Anatomical Structure Arrangement Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Rho Protein Signal Transduction Motor Neuron Axon Guidance Cellular Developmental Process Ventral Trunk Neural Crest Cell Migration Small GTPase-mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Plasma Membrane Bounded Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Ameboidal-type Cell Migration Trigeminal Ganglion Development Cell Migration Positive Regulation Of Cell Migration Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Negative Chemotaxis Neuron Migration Positive Regulation Of Locomotion Cranial Ganglion Development Trunk Neural Crest Cell Migration Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Migration Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Regulation Of Cell Motility Regulation Of Actin Filament-based Process Cell Motility Regulation Of Locomotion
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