MBD3 and ZNF277

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MBD3	ZNF277
Gene Name		methyl-CpG binding domain protein 3	zinc finger protein 277
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Methylation-dependent Chromatin Silencing Transcription, DNA-templated Tissue Development Histone Acetylation ATP-dependent Chromatin Remodeling	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To Hydrogen Peroxide Regulation Of Cellular Senescence
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS			Breast size ( 22747683)
Protein-Protein Interactions		28 interactors: AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 HDAC1 HIST3H3 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA1 MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZNF277	7 interactors: COIL DDB1 GNGT1 MBD3 NUTM1 ZBTB7B ZNF768
Entrez ID		53615	11179
HPRD ID		04653	05680
Ensembl ID		ENSG00000071655	ENSG00000198839
Uniprot IDs		O95983	Q9NRM2
PDB IDs
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Chromatin Organization Transcription, DNA-templated Chromosome Organization Chromatin Modification RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Remodeling RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification Histone Modification Negative Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Interaction With Symbiont Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3-K4 Demethylation Chromatin Assembly Or Disassembly Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Binding	Cellular Response To Light Stimulus Cellular Response To Radiation Positive Regulation By Virus Of Viral Protein Levels In Host Cell UV-damage Excision Repair Methylation-dependent Chromatin Silencing Positive Regulation Of Viral Release From Host Cell Cardiac Muscle Cell Apoptotic Process Response To Light Stimulus Muscle Cell Apoptotic Process Histone H2A Monoubiquitination Histone Modification Histone H2A Ubiquitination Response To Radiation Nucleotide-excision Repair, DNA Damage Removal Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Viral Release From Host Cell Ectoderm Development Regulation Of Rhodopsin Mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Chromatin Modification Rhodopsin Mediated Signaling Pathway Interaction With Symbiont Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Silencing Histone Ubiquitination Transcription, DNA-templated Eye Photoreceptor Cell Development Cellular Nitrogen Compound Metabolic Process Chromatin Organization RNA Biosynthetic Process Protein Monoubiquitination Photoreceptor Cell Development Eye Photoreceptor Cell Differentiation
Tagcloud ?		accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie	7q31 allelotyping chromosome d7s2502 d7s525 deletions diploid dock4 duplication elucidating elusive evolutionarily finger head hel hemizygous heterozygosity implicating island karyotypically localize loci ml3 monosomy myelodysplasia myelogenous portends preleukemic reagents
Tagcloud (Difference) ?		accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie	7q31 allelotyping chromosome d7s2502 d7s525 deletions diploid dock4 duplication elucidating elusive evolutionarily finger head hel hemizygous heterozygosity implicating island karyotypically localize loci ml3 monosomy myelodysplasia myelogenous portends preleukemic reagents
Tagcloud (Intersection) ?