MBD3 and TET1

Number of citations of the paper that reports this interaction (PMID 22196727)
88

Data Source:
BioGRID (pull down)

		MBD3	TET1
Gene Name		methyl-CpG binding domain protein 3	tet methylcytosine dioxygenase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Iron Ion Binding Zinc Ion Binding Structure-specific DNA Binding Methylcytosine Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Methylation-dependent Chromatin Silencing Transcription, DNA-templated Tissue Development Histone Acetylation ATP-dependent Chromatin Remodeling	Inner Cell Mass Cell Differentiation Transcription, DNA-templated Protein O-linked Glycosylation Gene Expression Chromatin Modification Stem Cell Maintenance Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Regulation Of DNA Methylation Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Demethylation Negative Regulation Of Methylation-dependent Chromatin Silencing
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance	TET1,2,3 and TDG demethylate DNA Epigenetic regulation of gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 HDAC1 HIST3H3 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA1 MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZNF277	1 interactors: MBD3
Entrez ID		53615	80312
HPRD ID		04653	09694
Ensembl ID		ENSG00000071655	ENSG00000138336
Uniprot IDs		O95983	Q8NFU7
PDB IDs
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Chromatin Organization Transcription, DNA-templated Chromosome Organization Chromatin Modification RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Remodeling RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification Histone Modification Negative Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Interaction With Symbiont Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3-K4 Demethylation Chromatin Assembly Or Disassembly Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Binding	Methylation-dependent Chromatin Silencing Chromatin Silencing ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation
Tagcloud ?		accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie	analytical analyzing briefly chapter clearly concepts converting details discovery emerging epigenetic evidences growing heterozygous hydroxymethylcytosine invaluable knockout mentioned methylation microrna modification noncoding opioid opioids others played reductions rnas subheading
Tagcloud (Difference) ?		accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie	analytical analyzing briefly chapter clearly concepts converting details discovery emerging epigenetic evidences growing heterozygous hydroxymethylcytosine invaluable knockout mentioned methylation microrna modification noncoding opioid opioids others played reductions rnas subheading
Tagcloud (Intersection) ?