MBD3 and TET1

Number of citations of the paper that reports this interaction (PubMedID 22196727)
59

Data Source:
BioGRID (pull down)

		MBD3	TET1
Description		methyl-CpG binding domain protein 3	tet methylcytosine dioxygenase 1
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex	Nucleus Chromosome Sin3-type Complex
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Iron Ion Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Metal Ion Binding Dioxygenase Activity DNA 5-methylcytosine Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Inner Cell Mass Cell Differentiation Chromatin Organization Chromatin Remodeling Protein O-linked Glycosylation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Stem Cell Population Maintenance Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species Epigenetic Regulation Of Gene Expression Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Childhood body mass index ( 33045005) Chronotype ( 30696823) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Pulse pressure ( 30224653) Triglycerides ( 30275531)
Interacting Genes		73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	1 interacting genes: MBD3
Entrez ID		53615	80312
HPRD ID		04653	09694
Ensembl ID		ENSG00000071655	ENSG00000138336
Uniprot IDs		O95983	Q8NFU7
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	6ASD
Enriched GO Terms of Interacting Partners?		NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification	B-WICH Complex RNA Polymerase Inhibitor Activity 7SK SnRNA Binding Negative Regulation Of Transcription By RNA Polymerase I Chromatin Remodeling Chromosome R-loop Processing Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Positive Regulation Of Dendritic Cell Cytokine Production Ventricular Cardiac Muscle Tissue Development Response To Bisphenol A Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Dendritic Cell Cytokine Production NuRD Complex SnoRNA Binding Chromatin Organization Regulation Of Cell Fate Specification Regulation Of Transcription By RNA Polymerase III Methyl-CpG Binding Positive Regulation Of Transcription By RNA Polymerase I MiRNA Binding Response To Exogenous DsRNA Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Nucleosomal DNA Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Response To DsRNA Regulation Of Transcription By RNA Polymerase I Negative Regulation Of RNA Biosynthetic Process RRNA Binding Regulation Of Cell Fate Commitment Heterochromatin Negative Regulation Of RNA Metabolic Process Constitutive Heterochromatin Formation Cardiac Muscle Tissue Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-stranded RNA Binding RNA Helicase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of RNA Metabolic Process
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