MECOM and CTBP2

Number of citations of the paper that reports this interaction (PMID 9724649)
95

Data Source:
HPRD (in vitro)

		MECOM	CTBP2
Gene Name		MDS1 and EVI1 complex locus	C-terminal binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Aggresome Nuclear Speck Intracellular Membrane-bounded Organelle	Nucleus Transcriptional Repressor Complex Cell Junction Synapse
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Retinoic Acid Receptor Binding NAD Binding
	Biological Process	In Utero Embryonic Development Neutrophil Homeostasis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Inflammatory Response Response To Bacterium Post-embryonic Development Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Development Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Regulation Of Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Regulation Of Cell Cycle Pericardium Development Hematopoietic Stem Cell Proliferation Renal System Development	Transcription, DNA-templated Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation Oxidation-reduction Process
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated repression of WNT target genes S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS		Aging (time to event) ( 21782286) Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Osteoporosis ( 23349225) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Systolic blood pressure ( 21909115)	Prostate cancer ( 18264096)
Protein-Protein Interactions		13 interactors: CREBBP CTBP1 CTBP2 HDAC1 HDAC4 KAT2B MBD3 PRMT1 SMAD1 SMAD2 SMAD3 SMAD4 SUMO1	67 interactors: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 HIC1 HIST3H3 HOXB5 IKZF1 IKZF2 KLF3 KLF8 LCOR MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RBBP8 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750
Entrez ID		2122	1488
HPRD ID		01310	04016
Ensembl ID		ENSG00000085276	ENSG00000175029
Uniprot IDs		C7FEN9 E7EQ57 Q03112 Q13465	P56545 Q5SQP8
PDB IDs			2OME
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression SMAD Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation Regulation Of RNA Metabolic Process Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Primary MiRNA Processing Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Embryo Development Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Pattern Specification Cellular Nitrogen Compound Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptidyl-lysine Modification	RNA Biosynthetic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Viral Process Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Developmental Process Cellular Process Multicellular Organismal Development Muscle Structure Development Muscle Organ Development Organ Development Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		admitted aggressive aml april attributed august d816v documentation eosinophilia homogeneous hypothesized infarction initially kit ldh leukemic man minor myeloproliferative myocardial neoplasm novo occurrence persisting runx1 splenomegaly thalassemia unrecognized v617f	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Difference) ?		admitted aggressive aml april attributed august d816v documentation eosinophilia homogeneous hypothesized infarction initially kit ldh leukemic man minor myeloproliferative myocardial neoplasm novo occurrence persisting runx1 splenomegaly thalassemia unrecognized v617f	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Intersection) ?