MBD3 and KDM5B

Number of citations of the paper that reports this interaction (PubMedID 21937684)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MBD3	KDM5B
Description		methyl-CpG binding domain protein 3	lysine demethylase 5B
Image
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	Nucleic Acid Binding DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Histone Binding Metal Ion Binding Dioxygenase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Single Fertilization Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of DNA-templated Transcription Rhythmic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Response To Fungicide Uterus Morphogenesis Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Estradiol Secretion
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS
Interacting Genes		73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	6 interacting genes: FOXG1 KDM1A MBD3 NRIP1 PAX9 RB1
Entrez ID		53615	10765
HPRD ID		04653	09251
Ensembl ID		ENSG00000071655	ENSG00000117139
Uniprot IDs		O95983	A0A3B3IS40 A0A3B3ITA8 Q9UGL1
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	2MA5 2MNY 2MNZ 5A1F 5A3N 5A3P 5A3T 5A3W 5FPL 5FPU 5FUN 5FUP 5FV3 5FY4 5FY5 5FY9 5FYB 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5LW9 5LWB 6EIN 6EIU 6EIY 6EJ0 6EJ1 6EK6 6H4Z 6H50 6H51 6H52 6RBI
Enriched GO Terms of Interacting Partners?		NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification	Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of Neuroblast Proliferation Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Neuron Maturation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Neuroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Neural Precursor Cell Proliferation Nucleoplasm Regulation Of Neurogenesis Positive Regulation Of Cell Development Regulation Of Nervous System Development Regulation Of Developmental Process Cerebral Cortex Development Ovarian Follicle Rupture Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Neural Precursor Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Response To Estradiol Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Cell Differentiation Pyramidal Neuron Migration To Cerebral Cortex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Heterochromatin Formation Chromatin Lock Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?