DDX23 and MIR214

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		DDX23	MIR214
Description		DEAD-box helicase 23	microRNA 214
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Chromosome Nucleolus U4/U6 X U5 Tri-snRNP Complex Extracellular Exosome Catalytic Step 2 Spliceosome	Nucleus RISC Complex Perinuclear Region Of Cytoplasm Extracellular Vesicle
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Cis Assembly Of Pre-catalytic Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing R-loop Processing	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Chemokine Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Necroptotic Process Cellular Response To Hypoxia Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Connective Tissue Replacement
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 21926972)	Height ( 31562340)
Interacting Genes		29 interacting genes: CEBPA CLK1 ERG MIR106B MIR128-1 MIR138-2 MIR141 MIR143 MIR19B2 MIR200B MIR200C MIR214 MIR25 MIR363 MIR429 MIR7-1 MIR7-2 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7G MIRLET7I PCM1 RNF10 TERF1 TERF2IP WBP4 WEE2-AS1	92 interacting genes: AIMP1 AIMP2 AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PTBP1 PTCD3 PUF60 PUM1 PUM2 QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM4B RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H11A ZFR ZNF346
Entrez ID		9416	406996
HPRD ID		09908
Ensembl ID		ENSG00000174243	ENSG00000283844
Uniprot IDs		B3KY11 Q9BUQ8
PDB IDs		3JCR 4NHO 6AH0 6QW6 6QX9 8H6E 8H6J 8Q7W 8Q7X 8Q91 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPK 8QXD 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of MRNA Metabolic Process Negative Regulation Of Interleukin-33 Production Positive Regulation Of Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Translation Regulation Of Multicellular Organismal Development Negative Regulation Of Multicellular Organismal Process Extracellular Vesicle Regulation Of Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of Developmental Process Regulation Of Vasculature Development Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Shelterin Complex Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Extracellular Space Nuclear Telomere Cap Complex Negative Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Macromolecule Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression Catalytic Step 2 Spliceosome Nucleoplasm Nucleus Spliceosomal Complex Cytoplasmic Stress Granule Regulation Of MRNA Processing MiRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of RNA Stability Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleolus TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Helicase Activity Negative Regulation Of Translation Positive Regulation Of Cytoplasmic Translation RNA Transport Positive Regulation Of Gene Expression Ligase Activity CRD-mediated MRNA Stabilization MRNA 5'-UTR Binding
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