SLX4 and SLX1A

Number of citations: 120 (PubMedID 37071664)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique), HPRD (two hybrid)

		SLX4	SLX1A
Name		SLX4 structure-specific endonuclease subunit	structure-specific endonuclease subunit SLX1A
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex	Nucleus Nucleoplasm Slx1-Slx4 Complex
	Molecular Function	DNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
GWAS		Type 2 diabetes ( 32499647 )	Brain morphology (MOSTest) ( 32665545 )
Novel Interactors		1 novel interactors: GLIS2	None recorded
Interacting Genes		9 interacting genes: APP EME1 ERCC4 ERG MUS81 PLK3 SLX1A UBC UBE2I	6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		84464	548593
HPRD ID		12537	18681
Ensembl ID		ENSG00000188827	ENSG00000132207
Uniprot IDs		Q8IY92	Q9BQ83
PDB IDs		4M7C 4UYI 4ZOU 7BU5 7TUJ	Not available
GO Terms Enriched among Interactors		Crossover Junction DNA Endonuclease Activity Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Nuclease Activity Telomere Organization Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Resolution Of Mitotic Recombination Intermediates Double-strand Break Repair Response To DNA Damage Checkpoint Signaling DNA Recombination Meiosis I Cell Cycle Process Endonuclease Activity Resolution Of DNA Recombination Intermediates Nucleoplasm Chromosome Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleus Nuclear Replication Fork Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Endonuclease Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Mitotic Cell Cycle DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Replication Fork Processing Negative Regulation Of Cell Cycle Phase Transition Regulation Of Telomere Maintenance Via Telomere Lengthening DNA Binding Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Chaperone-mediated Autophagy DNA Metabolic Process SUMO Conjugating Enzyme Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle	Resolution Of Meiotic Recombination Intermediates ERCC4-ERCC1 Complex Telomere Maintenance Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Telomere Organization Response To DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Recombination Meiosis I Cell Cycle Process DNA Damage Response Chromosome Organization DNA Repair Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Nucleotide-excision Repair Positive Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Cellular Response To Stress Endodeoxyribonuclease Complex DNA Metabolic Process Resolution Of Mitotic Recombination Intermediates Nucleotide-excision Repair Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Capping Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Telomere Maintenance T-circle Formation UV Protection Nuclease Activity Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Double-strand Break Repair Via Homologous Recombination Organelle Organization Recombinational Repair Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Reproductive Process Mitotic Recombination Nuclear Replication Fork Cellular Response To Radiation DNA Endonuclease Activity