SLX4 and SLX1A

Number of citations of the paper that reports this interaction (PMID 19596236)
118

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (two hybrid)

		SLX4	SLX1A
Gene Name		SLX4 structure-specific endonuclease subunit	SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleoplasm Cytoplasm Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex	Slx1-Slx4 Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity 3'-flap Endonuclease Activity	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Catalytic Activity Response To Intra-S DNA Damage Checkpoint Signaling	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP EME1 ERCC4 MUS81 SLX1A SLX4IP UBC	6 interactors: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		84464	548593
HPRD ID		12537	18681
Ensembl ID		ENSG00000188827	ENSG00000132207
Uniprot IDs		Q8IY92	Q9BQ83
PDB IDs		4M7C
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Metabolic Process DNA Catabolic Process, Endonucleolytic DNA Catabolic Process Cellular Response To Stress Response To Stress Cellular Macromolecule Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Regulation Of ERBB Signaling Pathway Recombinational Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Double-strand Break Repair Collateral Sprouting In Absence Of Injury DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Telomere Maintenance Via Telomere Shortening Intracellular Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nucleotide-excision Repair, DNA Incision Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Neuron Remodeling Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance	Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombination Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Endonucleolytic DNA Catabolic Process DNA Repair Cellular Response To Stress Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision DNA Metabolic Process Nucleotide-excision Repair Interstrand Cross-link Repair Aromatic Compound Catabolic Process Negative Regulation Of Telomere Maintenance UV Protection Double-strand Break Repair Nucleotide-excision Repair, DNA Damage Removal Regulation Of Telomere Maintenance Response To Stress Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Response To UV Cellular Response To Stimulus Response To Ionizing Radiation Response To Biotic Stimulus Post-embryonic Hemopoiesis DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Shortening Pyrimidine Dimer Repair By Nucleotide-excision Repair Regulation Of Organelle Organization Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Replicative Cell Aging Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Cellular Nitrogen Compound Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Aging
Tagcloud ?		btb catastrophe charged conjugating crosslink detrimental dispensable e3 endonuclease engages ercc1 fanconi fragile instead interacting interstrand ligase mitotic motifs recombination relies remarkably repair sims sumo sumoylates ubc9 ubz4 xpf
Tagcloud (Difference) ?		btb catastrophe charged conjugating crosslink detrimental dispensable e3 endonuclease engages ercc1 fanconi fragile instead interacting interstrand ligase mitotic motifs recombination relies remarkably repair sims sumo sumoylates ubc9 ubz4 xpf
Tagcloud (Intersection) ?