SLX4 and EME1

Number of citations of the paper that reports this interaction (PubMedID 37071664)
120

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down)

		SLX4	EME1
Description		SLX4 structure-specific endonuclease subunit	essential meiotic structure-specific endonuclease 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex	Nuclear Chromosome Chromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex
	Molecular Function	DNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding	DNA Binding Nuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Type 2 diabetes ( 32499647)
Interacting Genes		9 interacting genes: APP EME1 ERCC4 ERG MUS81 PLK3 SLX1A UBC UBE2I	6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2
Entrez ID		84464	146956
HPRD ID		12537	10937
Ensembl ID		ENSG00000188827	ENSG00000154920
Uniprot IDs		Q8IY92	Q96AY2
PDB IDs		4M7C 4UYI 4ZOU 7BU5 7TUJ	2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S 9F98 9F99 9F9A 9F9K 9F9L 9F9M
Enriched GO Terms of Interacting Partners?		Crossover Junction DNA Endonuclease Activity Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Nuclease Activity Telomere Organization Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Resolution Of Mitotic Recombination Intermediates Double-strand Break Repair Response To DNA Damage Checkpoint Signaling DNA Recombination Meiosis I Cell Cycle Process Endonuclease Activity Resolution Of DNA Recombination Intermediates Nucleoplasm Chromosome Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleus Nuclear Replication Fork Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Endonuclease Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Mitotic Cell Cycle DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Replication Fork Processing Negative Regulation Of Cell Cycle Phase Transition Regulation Of Telomere Maintenance Via Telomere Lengthening DNA Binding Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Chaperone-mediated Autophagy DNA Metabolic Process SUMO Conjugating Enzyme Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle	Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Positive Regulation Of T-circle Formation Slx1-Slx4 Complex Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Crossover Junction DNA Endonuclease Activity Telomeric D-loop Disassembly Telomeric Loop Disassembly T-circle Formation Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair Resolution Of Meiotic Recombination Intermediates Chromosome, Telomeric Region DNA Double-strand Break Processing Positive Regulation Of Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleotide-excision Repair Chromosome Organization Regulation Of Protein Catabolic Process Meiosis I Cell Cycle Process Endonuclease Activity Positive Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Nuclease Activity
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