SLX4 and EME1

Number of citations of the paper that reports this interaction (PMID 19596236)
118

Data Source:
BioGRID (pull down)

		SLX4	EME1
Gene Name		SLX4 structure-specific endonuclease subunit	essential meiotic structure-specific endonuclease 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleoplasm Cytoplasm Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex	Nucleus Nuclear Heterochromatin Nucleolus Cytoplasm
	Molecular Function	Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity 3'-flap Endonuclease Activity	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Catalytic Activity Response To Intra-S DNA Damage Checkpoint Signaling	DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP EME1 ERCC4 MUS81 SLX1A SLX4IP UBC	4 interactors: APP MUS81 SLX1A SLX4
Entrez ID		84464	146956
HPRD ID		12537	10937
Ensembl ID		ENSG00000188827	ENSG00000154920
Uniprot IDs		Q8IY92	Q96AY2
PDB IDs		4M7C	2ZIU 2ZIV 2ZIW 2ZIX
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Metabolic Process DNA Catabolic Process, Endonucleolytic DNA Catabolic Process Cellular Response To Stress Response To Stress Cellular Macromolecule Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Regulation Of ERBB Signaling Pathway Recombinational Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Double-strand Break Repair Collateral Sprouting In Absence Of Injury DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Telomere Maintenance Via Telomere Shortening Intracellular Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nucleotide-excision Repair, DNA Incision Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Neuron Remodeling Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance	DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Intra-S DNA Damage Checkpoint Signaling DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing DNA Catabolic Process DNA Recombination Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Double-strand Break Repair Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Axon Choice Point Recognition Nucleobase-containing Compound Metabolic Process Neuron Remodeling Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Response To Biotic Stimulus Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating
Tagcloud ?		btb catastrophe charged conjugating crosslink detrimental dispensable e3 endonuclease engages ercc1 fanconi fragile instead interacting interstrand ligase mitotic motifs recombination relies remarkably repair sims sumo sumoylates ubc9 ubz4 xpf	accordingly alleles break breaks carrying cytotoxic depleted disrupted disruption double eliminate endonucleolytic es excessive extensive fbh1 forks helicase hydroxyurea killing malignancies mediating mus81 nuclease occurring operates promoting replication strand
Tagcloud (Difference) ?		btb catastrophe charged conjugating crosslink detrimental dispensable e3 endonuclease engages ercc1 fanconi fragile instead interacting interstrand ligase mitotic motifs recombination relies remarkably repair sims sumo sumoylates ubc9 ubz4 xpf	accordingly alleles break breaks carrying cytotoxic depleted disrupted disruption double eliminate endonucleolytic es excessive extensive fbh1 forks helicase hydroxyurea killing malignancies mediating mus81 nuclease occurring operates promoting replication strand
Tagcloud (Intersection) ?