TOP2B and RANBP2

Number of citations: 33 (PubMedID 18394993)
Data Source: BioGRID (affinity chromatography technology, enzymatic study)

		TOP2B	RANBP2
Name		DNA topoisomerase II beta	RAN binding protein 2
Structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Ribonucleoprotein Complex	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket SUMO Ligase Complex Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Topoisomerase Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Binding ATP Binding Isomerase Activity Ribonucleoprotein Complex Binding Metal Ion Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity GTPase Activator Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Activator Activity SUMO Transferase Activity Small GTPase Binding Protein-containing Complex Binding Metal Ion Binding SUMO Ligase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Metabolic Process DNA Topological Change Axonogenesis B Cell Differentiation Forebrain Development Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Cellular Response To Hydrogen Peroxide Cellular Response To ATP Cellular Senescence Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Response To Amphetamine Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Gluconeogenesis Protein Folding NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Protein Sumoylation Negative Regulation Of Innate Immune Response Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Export Centrosome Localization
Pathways		SUMOylation of DNA replication proteins	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants
Drugs		Dexrazoxane Daunorubicin Etoposide Dactinomycin Doxorubicin Norfloxacin Phosphoaminophosphonic Acid-Adenylate Ester Amonafide Technetium Tc-99m ciprofloxacin ZEN-012 Becatecarin Declopramide 3'-THIO-THYMIDINE-5'-PHOSPHATE	None
GWAS		Chronic obstructive pulmonary disease ( 30804561 )	Attention deficit hyperactivity disorder ( 29325848 ) Beard thickness ( 26926045 ) Monobrow thickness ( 26926045 ) Scalp hair shape ( 26926045 )
Novel Interactors		None recorded	1 novel interactors: GCC2
Interacting Genes		22 interacting genes: BRCA1 CD3E CEBPA CSNK2B ERG HDAC1 HDAC2 LAMTOR5 MAPK3 RANBP2 RARA RNF4 SUMO1 SUMO2 TOP2A TOPBP1 TP53 UBC UBE2I USP7 XPO1 XRCC5	40 interacting genes: AKAP13 ARID4B CALM1 CDCA8 CEBPA CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MAP2K7 MDM2 MYBPC2 NR5A2 NUP62 NXF1 OPN1LW OPN1MW PDLIM3 PRKN PTEN RAN RANGAP1 RNF10 SENP1 SP100 SUMO1 SUMO2 TAF1 TNPO1 TOP2B UBE2I UBTD1 WAS XPO1 XPOT
Entrez ID		7155	5903
HPRD ID		00537	03111
Ensembl ID		ENSG00000077097	ENSG00000153201
Uniprot IDs		Q02880 Q59H80	P49792
PDB IDs		3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ 5ZAD 5ZEN 5ZQF 5ZRF 7QFN 7QFO 7YQ8 7ZBG 8KE7	1RRP 1XKE 1Z5S 2LAS 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW 5CLL 5CLQ 7MNJ 7MNK 7MNL 7MNM 7MNN 7MNO 7MNP 7MNQ 7MNR 7MNS 7MNT 7MNU 7MNV 7MNW 7MNX 7MNY 7MNZ 7R5J 7R5K 9B62
GO Terms Enriched among Interactors		PML Body Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Proteolysis Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Nuclear Body Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Enzyme Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Histone Deacetylase Binding Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Transcription Cis-regulatory Region Binding Protein Tag Activity Cellular Response To Stress Protein Modification By Small Protein Conjugation Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription P53 Binding SUMO Transferase Activity Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction	Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Nucleoplasm Protein Localization To Nucleus Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Transport Nuclear Import Signal Receptor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Organelle Nuclear Localization Sequence Binding Regulation Of Intracellular Protein Transport Establishment Of Localization In Cell Presynaptic Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intracellular Transport Positive Regulation Of RNA Biosynthetic Process Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Nucleus Import Into Nucleus Small GTPase Binding Nuclear Export Regulation Of Proteasomal Protein Catabolic Process Cellular Localization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription SUMO Transferase Activity Nuclear Membrane Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process NLS-bearing Protein Import Into Nucleus Regulation Of RNA Biosynthetic Process Intracellular Protein Transport Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Postsynaptic Cytosol Nuclear Envelope Regulation Of Protein Transport Establishment Of Protein Localization To Organelle Cytosol Cytoplasm RNA Transport RNA Export From Nucleus NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Macromolecule Biosynthetic Process