TOP2B

Description		DNA topoisomerase II beta
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Topoisomerase Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Binding ATP Binding Isomerase Activity Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Metabolic Process DNA Topological Change Axonogenesis B Cell Differentiation Forebrain Development Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Cellular Response To Hydrogen Peroxide Cellular Response To ATP Cellular Senescence Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		SUMOylation of DNA replication proteins
Drugs		Dexrazoxane Daunorubicin Etoposide Dactinomycin Doxorubicin Norfloxacin Phosphoaminophosphonic Acid-Adenylate Ester Amonafide Technetium Tc-99m ciprofloxacin ZEN-012 Becatecarin Declopramide 3'-THIO-THYMIDINE-5'-PHOSPHATE
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		22 interacting genes: BRCA1 CD3E CEBPA CSNK2B ERG HDAC1 HDAC2 LAMTOR5 MAPK3 RANBP2 RARA RNF4 SUMO1 SUMO2 TOP2A TOPBP1 TP53 UBC UBE2I USP7 XPO1 XRCC5
Entrez ID		7155
HPRD ID		00537
Ensembl ID		ENSG00000077097
Uniprot IDs		Q02880 Q59H80
PDB IDs		3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ 5ZAD 5ZEN 5ZQF 5ZRF 7QFN 7QFO 7YQ8 7ZBG 8KE7
Enriched GO Terms of Interacting Partners?		PML Body Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Proteolysis Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Nuclear Body Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Enzyme Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Histone Deacetylase Binding Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Transcription Cis-regulatory Region Binding Protein Tag Activity Cellular Response To Stress Protein Modification By Small Protein Conjugation Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription P53 Binding SUMO Transferase Activity Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction
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