SNRNP200 and PTEN

Number of citations of the paper that reports this interaction (PubMedID 31685992)
0

Data Source:
BioGRID (pull down)

		SNRNP200	PTEN
Description		small nuclear ribonucleoprotein U5 subunit 200	phosphatase and tensin homolog
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Plasma Membrane Cilium Membrane Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Apical Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Synapse
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity Enzyme Binding PDZ Domain Binding Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Identical Protein Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding Ubiquitin Ligase Activator Activity
	Biological Process	Cis Assembly Of Pre-catalytic Spliceosome Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) MRNA Splicing, Via Spliceosome Osteoblast Differentiation MRNA Processing RNA Splicing	Osteoblast Differentiation Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Apoptotic Process Spindle Assembly Involved In Female Meiosis Neuron-neuron Synaptic Transmission Nervous System Development Synapse Assembly Central Nervous System Development Heart Development Learning Or Memory Locomotory Behavior Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Cell Migration Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Migration Adult Behavior Regulation Of Protein Stability Central Nervous System Myelin Maintenance Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Social Behavior Maternal Behavior Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Locomotor Rhythm Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Organ Growth Phosphatidylinositol Dephosphorylation Forebrain Morphogenesis Cell Motility Negative Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Keratinocyte Migration Regulation Of Cell Cycle Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Rhythmic Synaptic Transmission Synapse Maturation Prepulse Inhibition Dendritic Spine Morphogenesis Regulation Of Biological Quality Cellular Response To Electrical Stimulus Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2
Drugs			Phosphatidylethanolamine
Diseases		Retinitis pigmentosa (RP)	Vulvar cancer Breast cancer Malignant melanoma Prostate cancer Hepatocellular carcinoma Small cell lung cancer Endometrial Cancer Glioma
GWAS			Alanine aminotransferase levels ( 33547301) Ambidextrousness ( 32989287) Birth weight ( 31043758) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fasting insulin ( 34059833) Height ( 31562340) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mercury levels ( 26025379) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 32888494) Plateletcrit ( 32888494) Psoriasis ( 28537254) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) Thyroid stimulating hormone levels ( 32769997 30367059) Type 2 diabetes ( 32499647 24509480) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		33 interacting genes: APC BARD1 BCAS2 BRCA1 CEBPA CHMP1B CREBBP DHX38 DUX4 ECT2 ERG GNMT GRB2 HSPB1 LCOR LSM8 MEGF10 PIN1 PRPF3 PRPF31 PRPF6 PTEN RNF10 RNF113A SF3B3 SMNDC1 SUMO2 UBE2I USP19 USP7 VHL YWHAB YWHAG	376 interacting genes: AATK ABCF2 ACTL6A ADAR AFP AKAP12 AKT1 ALYREF AMOT ANAPC10 ANAPC7 ANG ANP32B ANP32E ANXA2 AR ARF4 ARMCX3 ASCC3 ATM ATP5F1A ATP5F1C BCAR1 BEX1 BGLT3 BUB3 CACTIN-AS1 CAD CALM1 CAMK2G CAV1 CBL CCDC180 CCDC47 CCND2 CCT2 CCT3 CCT4 CCT6A CCT8 CDC27 CEP170 CEP97 CFL1 CHD4 CHGB CMAS COPA COPB1 COPS6 CREB1 CSNK1A1 CSNK2A1 CSNK2A2 CUL4B CXCL1 CXXC1 DAP3 DAXX DBN1 DCAF11 DCAF13 DDB1 DDOST DDX1 DDX21 DDX24 DDX47 DDX50 DHX15 DHX9 DLC1 DLG1 DNAJA1 DNAJA2 DNAJA3 DNAJB6 DNAJC10 DPM1 DRG1 DSP EEF2 EIF4E EIF6 EML1 EPHA2 EPRS1 ERBB3 ESR1 EXOSC1 EXOSC2 EXOSC4 EXOSC5 EXOSC7 FARSA FARSB FASN FBL FBXW11 FLNA FOXK1 FUBP3 GEMIN4 GNAI1 GNAI2 GNB4 GNL3 GPC4 GSTM2 GTF3C2 GTF3C3 GTF3C5 H2AC4 H2AX HADHA HBA1 HNRNPA1 HNRNPA3 HNRNPAB HNRNPUL1 HSD17B1 HSD17B10 HSP90B1 HSPA4 HSPA4L HSPA8 HSPBP1 HSPD1 HSPH1 IL24 ILF2 ILF3 INS IPO5 IPO7 IRS4 ITPRID2 JUP KBTBD4 KDM1A KPNB1 LATS1 LGALS1 LIMA1 LINC00839 LINC01198 LINC02023 LMNB1 LRPPRC LTV1 MAGED2 MAGI2 MAGI3 MAP2K3 MAST1 MAST2 MAST3 MATR3 MCM2 MCM3 MCM5 MCRS1 MDC1 MDN1 METTL26 MEX3C MKI67 MME MPRIP MRPS22 MRPS23 MRPS27 MRPS28 MRPS7 MRPS9 MSH6 MTHFD2 MVP MYBBP1A MYC MYH10 MYL12A MYO1B MYO1C MYO1D MYOF NACA NCBP1 NCF1 NDFIP1 NEDD4 NGB NHERF1 NHERF2 NOP56 NOP58 NPM3 NUMB OSGIN1 PBK PBRM1 PCNA PDGFRB PELO PELP1 PHB1 PHB2 PICK1 PIK3R1 PKM PLEC PLK1 POLDIP2 POLR1A POLR2A POLR2B POLR2H POP1 PPL PPP1CA PPP2CA PRDX1 PRDX3 PRKDC PRPF19 PRPF8 PSMD3 PSMD4 PSMD7 PTDSS1 PTK7 PURA PXN QPCTL RAD21 RANBP2 RANGAP1 RBBP5 RBM4 RCC2 RCN1 RFC3 RFC4 RFC5 RING1 RNF31 RPL10 RPL10A RPL12 RPL13 RPL13A RPL14 RPL17 RPL18A RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL27 RPL27A RPL28 RPL30 RPL31 RPL32 RPL34 RPL36 RPL38 RPL7 RPLP0 RPLP2 RPN2 RPP30 RPP38 RPP40 RPS11 RPS13 RPS15 RPS15A RPS17 RPS2 RPS20 RPS23 RPS25 RPS26 RPS27 RPS27A RPS3 RPS4X RPS5 RPS6 RPS9 RSL1D1 RYBP S100A8 S100A9 SDC1 SDC4 SDCBP SEC61A1 SET SETX SHARPIN SHROOM3 SIN3A SIRT4 SKP1 SLC25A1 SLC25A13 SLC25A3 SLC25A5 SMARCA4 SMARCA5 SMC2 SMC4 SMCHD1 SMURF1 SNAI1 SNRNP200 SNRPA1 SNRPB2 SNRPD1 SNTB2 SNX27 SPOP SPTAN1 SPTBN1 SRP14 SSB SSR4 SSRP1 STAG2 STK11 STRAP SUDS3 SUGP2 TCF25 TCP1 TECR TERF2IP THOC2 THOC3 THOC6 TMEFF1 TNKS TNKS2 TNPO3 TP53 TP53BP1 TRIM25 TRIM28 TRMO TUBA1B TUBB TUBB4B TUFM TWIST1 TXN U2AF1 UBE2I UBE2L3 UPF1 USP7 USP9X UTP14A UTRN WWP1 WWP2 XRCC5 XRCC6 YAF2 YAP1 YES1 YTHDC2 YTHDF2 ZNF326
Entrez ID		23020	5728
HPRD ID		03391	03431
Ensembl ID		ENSG00000144028	ENSG00000171862
Uniprot IDs		O75643	F6KD01 P60484
PDB IDs		2Q0Z 3JCR 4F91 4F92 4F93 4KIT 5O9Z 5URJ 5URK 5URM 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6QDV 6QW6 6QX9 6S8O 6S8Q 6S9I 7A5P 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS1 7OS2 7PX3 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8BCH 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP9 8QPA 8QPB 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O 9FMD	1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ 7JTX 7JUK 7JUL 7JVX 7PC7 8X3S
Enriched GO Terms of Interacting Partners?		Nucleoplasm Spliceosomal Complex RNA Splicing, Via Transesterification Reactions U2-type Precatalytic Spliceosome Nucleus Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing Post-translational Protein Modification Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Protein Modification Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Primary Metabolic Process Nuclear Speck MRNA Metabolic Process RNA Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein Modification By Small Protein Conjugation Spliceosomal Tri-snRNP Complex Assembly Protein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Stability Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of Metabolic Process Protein Kinase C Inhibitor Activity Cellular Response To Ionizing Radiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein K6-linked Ubiquitination Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To Radiation Regulation Of Cell Cycle BRCA1-B Complex Postsynaptic Cytosol U2-type Spliceosomal Complex RNA Processing Catalytic Step 2 Spliceosome	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Macromolecule Metabolic Process Translation Nucleolus Nucleoplasm Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cytosol Nucleus Cytosolic Large Ribosomal Subunit Cytoplasm RNA Metabolic Process Extracellular Exosome Focal Adhesion RRNA Metabolic Process Protein Metabolic Process Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Biogenesis RNA Processing Regulation Of DNA Metabolic Process Protein Binding Small Ribosomal Subunit ATP Binding Chromosome, Telomeric Region ATP Hydrolysis Activity Small-subunit Processome Positive Regulation Of DNA Biosynthetic Process RRNA Processing Positive Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ribosomal Small Subunit Biogenesis MRNA Metabolic Process Nucleotide Binding DNA Metabolic Process Protein Localization To Organelle Nucleocytoplasmic Transport Nuclear Transport Regulation Of Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus ATP-dependent Protein Folding Chaperone Positive Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Via Telomerase Chromosome Cadherin Binding
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