SNRNP200 and SMNDC1

Number of citations of the paper that reports this interaction (PubMedID 11331595)
55

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SNRNP200	SMNDC1
Description		small nuclear ribonucleoprotein U5 subunit 200	survival motor neuron domain containing 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Plasma Membrane Cilium Membrane Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Nuclear Speck
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Cis Assembly Of Pre-catalytic Spliceosome Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) MRNA Splicing, Via Spliceosome Osteoblast Differentiation MRNA Processing RNA Splicing	RNA Splicing, Via Transesterification Reactions MRNA Processing Apoptotic Process RNA Splicing
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS			Crohn's disease ( 23850713) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: APC BARD1 BCAS2 BRCA1 CEBPA CHMP1B CREBBP DHX38 DUX4 ECT2 ERG GNMT GRB2 HSPB1 LCOR LSM8 MEGF10 PIN1 PRPF3 PRPF31 PRPF6 PTEN RNF10 RNF113A SF3B3 SMNDC1 SUMO2 UBE2I USP19 USP7 VHL YWHAB YWHAG	6 interacting genes: CEBPA H3-4 KPNB1 PRPF19 SNRNP200 SNRPB
Entrez ID		23020	10285
HPRD ID		03391	04627
Ensembl ID		ENSG00000144028	ENSG00000119953
Uniprot IDs		O75643	O75940
PDB IDs		2Q0Z 3JCR 4F91 4F92 4F93 4KIT 5O9Z 5URJ 5URK 5URM 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6QDV 6QW6 6QX9 6S8O 6S8Q 6S9I 7A5P 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS1 7OS2 7PX3 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8BCH 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP9 8QPA 8QPB 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O 9FMD	4A4F 4A4H 8POI
Enriched GO Terms of Interacting Partners?		Nucleoplasm Spliceosomal Complex RNA Splicing, Via Transesterification Reactions U2-type Precatalytic Spliceosome Nucleus Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing Post-translational Protein Modification Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Protein Modification Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Primary Metabolic Process Nuclear Speck MRNA Metabolic Process RNA Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein Modification By Small Protein Conjugation Spliceosomal Tri-snRNP Complex Assembly Protein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Stability Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of Metabolic Process Protein Kinase C Inhibitor Activity Cellular Response To Ionizing Radiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein K6-linked Ubiquitination Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To Radiation Regulation Of Cell Cycle BRCA1-B Complex Postsynaptic Cytosol U2-type Spliceosomal Complex RNA Processing Catalytic Step 2 Spliceosome	Catalytic Step 2 Spliceosome U2-type Catalytic Step 1 Spliceosome MRNA Splicing, Via Spliceosome Spliceosomal Complex Small Nuclear Ribonucleoprotein Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions U5 SnRNP U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Nucleoplasm RNA Splicing Cellular Component Assembly MRNA Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization Response To Vitamin B2 C/EBP Complex U2 SnRNP Binding Cis Assembly Of Pre-catalytic Spliceosome MRNA Metabolic Process CHOP-C/EBP Complex SnRNP Binding White Fat Cell Proliferation Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Histone Pre-mRNA DCP Binding Spermatogonial Cell Division Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Phenylpropanoid Nucleic Acid Metabolic Process U7 SnRNP RNA Processing Histone Pre-mRNA 3'end Processing Complex U1 SnRNP Binding DNA Replication-dependent Chromatin Assembly Protein Domain Specific Binding Nucleus Fat Cell Proliferation 7-methylguanosine Cap Hypermethylation Importin-alpha Family Protein Binding NLS-dependent Protein Nuclear Import Complex
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