PUF60 and MIR29A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PUF60	MIR29A
Description		poly(U) binding splicing factor 60	microRNA 29a
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cell Junction Ribonucleoprotein Complex	Extracellular Space Cytoplasm Mitochondrion RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding	MRNA 3'-UTR Binding LncRNA Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Processing Apoptotic Process RNA Splicing	Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Collagen Biosynthetic Process MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Epigenetic Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Circulating Fibrinogen Levels Positive Regulation Of Wound Healing Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Basal cell carcinoma ( 31174203) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 25086665) Red blood cell count ( 32888494) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 32888494)
Interacting Genes		109 interacting genes: ARL8A BORCS5 CACNA1A CCNC CD101 CEBPA CHD3 CPEB2 DDIT4L DDX50 ERG ERP29 FBXO7 FHL2 FTHL17 FUBP1 H1-2 ID3 IQCN KHDC4 MED28 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I MREG MYCBP2 OGT PCBP1 PCBP3 PPP1R16A PTBP2 QRICH1 RAD23B RAP1GDS1 SAP30BP SDCBP SF1 SIAH1 SNRPA SNRPF SRSF11 SUGP1 TAF2 TH U2AF2 UBE2I UBTFL1 UPF2 VIM YWHAG ZG16	84 interacting genes: AIMP2 APOBEC3B AQR C1QBP CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 FAM98A FUS HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 RARS1 RBFOX2 RBM14 RBM4 RBM45 RBM47 RBMS1 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TENT2 TIAL1 TRA2B TRIM25 TRIM71 UPF1 USP36 UTP20 YBX1 YBX3 ZC3H7A ZC3H7B ZNF346
Entrez ID		22827	407021
HPRD ID		18051
Ensembl ID		ENSG00000179950	ENSG00000284032
Uniprot IDs		E9PL19 E9PQ56 H0YEM1 Q9UHX1
PDB IDs		2DNY 2KXF 2KXH 2QFJ 3DXB 3UE2 3US5 3UWT 5KVY 5KW1 5KW6 5KWQ 6LUR 6SLO 7Q8A 7Z3X
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis MRNA Destabilization Negative Regulation Of Vasculature Development RNA Destabilization Regulation Of Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Locomotion Extracellular Space Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility	RNA Binding RNA Processing Nucleic Acid Binding RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleus Post-transcriptional Regulation Of Gene Expression Regulation Of RNA Splicing Ribonucleoprotein Complex MiRNA Binding Nucleoplasm MRNA 3'-UTR Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Stabilization Regulation Of MRNA Stability MRNA Stabilization Regulation Of Macromolecule Metabolic Process MiRNA Processing Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Catabolic Process Ligase Activity
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