PUF60 and CCNC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PUF60	CCNC
Description		poly(U) binding splicing factor 60	cyclin C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cell Junction Ribonucleoprotein Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Mediator Complex CKM Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Identical Protein Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Processing Apoptotic Process RNA Splicing	Regulation Of Transcription By RNA Polymerase II G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA Splicing - Major Pathway	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS			Daytime nap ( 33568662) Erectile dysfunction ( 30297428) Longevity (100 years and older) ( 33948810) Refractive error ( 32231278)
Interacting Genes		109 interacting genes: ARL8A BORCS5 CACNA1A CCNC CD101 CEBPA CHD3 CPEB2 DDIT4L DDX50 ERG ERP29 FBXO7 FHL2 FTHL17 FUBP1 H1-2 ID3 IQCN KHDC4 MED28 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I MREG MYCBP2 OGT PCBP1 PCBP3 PPP1R16A PTBP2 QRICH1 RAD23B RAP1GDS1 SAP30BP SDCBP SF1 SIAH1 SNRPA SNRPF SRSF11 SUGP1 TAF2 TH U2AF2 UBE2I UBTFL1 UPF2 VIM YWHAG ZG16	79 interacting genes: ASH2L BLOC1S2 BTBD2 CCHCR1 CCNH CDK3 CDK8 CDKN2B CFAP53 CKS1B CRX DYDC1 ERCC3 ESR2 FAM161A FAM50B FAM90A1 FOXP2 FOXR2 GADD45GIP1 GLYR1 GOLGA2 GPC4 HACE1 HSPB1 ISY1 KRT13 KRT15 KRT16 KRT27 KRT31 KRT34 LCN2 LZTS2 MBD3 MBIP MCM2 MED8 MEOX2 MGST3 MYO15B NDUFB7 NEFL NMNAT1 NRBF2 PAX5 PLEKHO2 PLIN3 PNMA5 POU6F2 PRPF18 PUF60 RB1 RBM41 REL RFC5 RIBC1 RPA2 RUSC1 SERTAD3 SHC3 SPAG8 TADA3 TCEANC TEPSIN TEX12 TP63 TRAF3IP3 TRIM39 TRIM54 UBE2K VHL VTA1 ZFP90 ZNF18 ZNF426 ZNF620 ZNF688 ZNF792
Entrez ID		22827	892
HPRD ID		18051	00456
Ensembl ID		ENSG00000179950	ENSG00000112237
Uniprot IDs		E9PL19 E9PQ56 H0YEM1 Q9UHX1	E5RFK5 G5E954 P24863 Q7Z4L3
PDB IDs		2DNY 2KXF 2KXH 2QFJ 3DXB 3UE2 3US5 3UWT 5KVY 5KW1 5KW6 5KWQ 6LUR 6SLO 7Q8A 7Z3X	3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis MRNA Destabilization Negative Regulation Of Vasculature Development RNA Destabilization Regulation Of Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Locomotion Extracellular Space Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility	Nucleus Intermediate Filament Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament DNA Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Chromatin Cytoskeleton Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Structural Molecule Activity Axonemal A Tubule Inner Sheath Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Epidermis Development Regulation Of Metabolic Process Importin-alpha Family Protein Binding Morphogenesis Of An Epithelium Regulation Of Mitotic Cell Cycle Phase Transition DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Phase Transition Anterograde Axonal Transport
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