LONP1 and ECSIT

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		LONP1	ECSIT
Gene Name		lon peptidase 1, mitochondrial	ECSIT signalling integrator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Nucleoid	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding ADP Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding Mitochondrial Light Strand Promoter Anti-sense Binding Mitochondrial Heavy Strand Promoter Anti-sense Binding Mitochondrial Light Strand Promoter Sense Binding Mitochondrial Heavy Strand Promoter Sense Binding	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Mitochondrial Genome Maintenance Response To Hypoxia Misfolded Or Incompletely Synthesized Protein Catabolic Process Mitochondrion Organization Aging Response To Hormone Response To Aluminum Ion Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Chaperone-mediated Protein Complex Assembly Protein Homooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Oxidation-dependent Protein Catabolic Process Regulation Of Mitochondrial DNA Replication	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: A2M APOE CDC37 CYP2C8 ECSIT IFIT3 IFIT5 LOXL4 MAST1 RNF32	42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		9361	51295
HPRD ID		05689	12225
Ensembl ID		ENSG00000196365	ENSG00000130159
Uniprot IDs		B3KPH8 F5GZ27 P36776 Q8N8K8	K7EMM0 Q9BQ95
PDB IDs		2X36
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidoreductase Activity Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Maintenance Of Location In Cell Defense Response To Virus Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Tau-protein Kinase Activity Regulation Of Presynaptic Membrane Organization Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Very-low-density Lipoprotein Particle Remodeling Innate Immune Response Positive Regulation Of Cholesterol Esterification Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering High-density Lipoprotein Particle Assembly Response To External Stimulus Positive Regulation Of Phospholipid Transport Omega-hydroxylase P450 Pathway Chylomicron Remnant Clearance Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Cellular Response To Interferon-alpha Regulation Of Innate Immune Response Negative Regulation Of Beta-amyloid Formation CGMP-mediated Signaling Exit From Mitosis Low-density Lipoprotein Particle Remodeling Cholesterol Catabolic Process Response To Virus Negative Regulation Of Cholesterol Transport Establishment Of Localization In Cell	Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?		2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?