LONP1 and IFIT5

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		LONP1	IFIT5
Description		lon peptidase 1, mitochondrial	interferon induced protein with tetratricopeptide repeats 5
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Mitochondrial Nucleoid	Cytosol Plasma Membrane IkappaB Kinase Complex Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Apical Part Of Cell
	Molecular Function	Nucleotide Binding Mitochondrial Promoter Sequence-specific DNA Binding DNA Binding Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity ATP Hydrolysis Activity PH Domain Binding Identical Protein Binding ADP Binding Insulin Receptor Substrate Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding	TRNA Binding RNA Cap Binding Double-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding
	Biological Process	Response To Hypoxia Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Mitochondrion Organization Response To Hormone Response To Aluminum Ion Protein Catabolic Process Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Mitochondrial Protein Catabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Chaperone-mediated Protein Complex Assembly Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Assembly Oxidation-dependent Protein Catabolic Process	Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus
Pathways		Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		12 interacting genes: A2M APOE CDC37 CDC42 CYP2C8 ECSIT IFIT3 IFIT5 LOXL4 MAST1 RNF10 RNF32	16 interacting genes: A2M APOE CDC37 ECSIT H19 IFIT3 LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2 TTC3
Entrez ID		9361	24138
HPRD ID		05689	17130
Ensembl ID		ENSG00000196365	ENSG00000152778
Uniprot IDs		P36776	Q13325
PDB IDs		2X36 6WYS 6WZV 6X1M 6X27 7KRZ 7KSL 7KSM 7NFY 7NG4 7NG5 7NGC 7NGF 7NGL 7NGP 7NGQ 7OXO 7P09 7P0B 7P0M 8OJL 8OKA 8OM7 8OVF 8OVG 9CC0 9CC3	3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Viral Life Cycle Antioxidant Activity Amyloid Precursor Protein Metabolic Process Regulation Of Viral Process Regulation Of Innate Immune Response Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Response To Stress Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Magnesium Ion Binding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Respiratory Burst Involved In Inflammatory Response Oxidation-dependent Protein Catabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle HSP90-CDC37 Chaperone Complex Regulation Of Blood Coagulation Regulation Of Hemostasis
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