LONP1 and CYP2C8

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		LONP1	CYP2C8
Gene Name		lon peptidase 1, mitochondrial	cytochrome P450, family 2, subfamily C, polypeptide 8
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Nucleoid	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding ADP Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding Mitochondrial Light Strand Promoter Anti-sense Binding Mitochondrial Heavy Strand Promoter Anti-sense Binding Mitochondrial Light Strand Promoter Sense Binding Mitochondrial Heavy Strand Promoter Sense Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Caffeine Oxidase Activity Aromatase Activity
	Biological Process	Mitochondrial Genome Maintenance Response To Hypoxia Misfolded Or Incompletely Synthesized Protein Catabolic Process Mitochondrion Organization Aging Response To Hormone Response To Aluminum Ion Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Chaperone-mediated Protein Complex Assembly Protein Homooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Oxidation-dependent Protein Catabolic Process Regulation Of Mitochondrial DNA Replication	Organic Acid Metabolic Process Xenobiotic Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS			Immune response to smallpox vaccine (IL-6) ( 22542470) Osteonecrosis of the jaw ( 18594024) Response to clopidogrel therapy ( 19706858) Warfarin maintenance dose ( 23755828)
Protein-Protein Interactions		10 interactors: A2M APOE CDC37 CYP2C8 ECSIT IFIT3 IFIT5 LOXL4 MAST1 RNF32	11 interactors: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RNF32
Entrez ID		9361	1558
HPRD ID		05689	03083
Ensembl ID		ENSG00000196365	ENSG00000138115
Uniprot IDs		B3KPH8 F5GZ27 P36776 Q8N8K8	B7Z1F5 P10632
PDB IDs		2X36	1PQ2 2NNH 2NNI 2NNJ 2VN0
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidoreductase Activity Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Maintenance Of Location In Cell Defense Response To Virus Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Tau-protein Kinase Activity Regulation Of Presynaptic Membrane Organization Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Very-low-density Lipoprotein Particle Remodeling Innate Immune Response Positive Regulation Of Cholesterol Esterification Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering High-density Lipoprotein Particle Assembly Response To External Stimulus Positive Regulation Of Phospholipid Transport Omega-hydroxylase P450 Pathway Chylomicron Remnant Clearance Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Cellular Response To Interferon-alpha Regulation Of Innate Immune Response Negative Regulation Of Beta-amyloid Formation CGMP-mediated Signaling Exit From Mitosis Low-density Lipoprotein Particle Remodeling Cholesterol Catabolic Process Response To Virus Negative Regulation Of Cholesterol Transport Establishment Of Localization In Cell	Regulation Of Inclusion Body Assembly Response To Stress Protein Metabolic Process Exocytosis Oxidation-dependent Protein Catabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Beta-amyloid Formation Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of Oxidoreductase Activity Response To Stimulus Response To Oxidative Stress Regulation Of Cellular Component Organization Extracellular Matrix Disassembly Establishment Of Localization In Cell Positive Regulation Of Neurofibrillary Tangle Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Cellular Response To Stimulus Secretion By Cell Immune System Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cell Projection Organization Regulation Of Catalytic Activity Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Cellular Localization Positive Regulation Of Cellular Protein Catabolic Process Maintenance Of Location In Cell Regulation Of Axonogenesis Secretion Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization
Tagcloud ?		2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen	allele apolipoprotein associations cardiotoxicity commonly comt conform epsilon4 failed fatigue genetic genotype guidelines il6 impairment listed lle655val met neuropathy polymorphisms reporting strega systematic toxicities transparent underlying val variant variants
Tagcloud (Difference) ?		2161c aggregated amish ancestral anomalies arg721gly auricular backgrounds canada codas come exome german homo homohexameric localize lymphoblastoid mennonite mtdna oligomerizes pocket proteostasis recombinantly sanger spare substitutions swiss swollen	allele apolipoprotein associations cardiotoxicity commonly comt conform epsilon4 failed fatigue genetic genotype guidelines il6 impairment listed lle655val met neuropathy polymorphisms reporting strega systematic toxicities transparent underlying val variant variants
Tagcloud (Intersection) ?