LONP1

Description		lon peptidase 1, mitochondrial
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Mitochondrial Nucleoid
	Molecular Function	Nucleotide Binding Mitochondrial Promoter Sequence-specific DNA Binding DNA Binding Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity ATP Hydrolysis Activity PH Domain Binding Identical Protein Binding ADP Binding Insulin Receptor Substrate Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding
	Biological Process	Response To Hypoxia Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Mitochondrion Organization Response To Hormone Response To Aluminum Ion Protein Catabolic Process Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Mitochondrial Protein Catabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Chaperone-mediated Protein Complex Assembly Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Assembly Oxidation-dependent Protein Catabolic Process
Pathways		Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Novel Interacting Genes		1 novel interacting genes: KEAP1
Interacting Genes		12 interacting genes: A2M APOE CDC37 CDC42 CYP2C8 ECSIT IFIT3 IFIT5 LOXL4 MAST1 RNF10 RNF32
Entrez ID		9361
HPRD ID		05689
Ensembl ID		ENSG00000196365
Uniprot IDs		P36776
PDB IDs		2X36 6WYS 6WZV 6X1M 6X27 7KRZ 7KSL 7KSM 7NFY 7NG4 7NG5 7NGC 7NGF 7NGL 7NGP 7NGQ 7OXO 7P09 7P0B 7P0M 8OJL 8OKA 8OM7 8OVF 8OVG 9CC0 9CC3
Enriched GO Terms of Interacting Partners?
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