KARS and DARS2

Number of citations of the paper that reports this interaction (PMID 9878398)
36

Data Source:
BioGRID (two hybrid)

		KARS	DARS2
Gene Name		lysyl-tRNA synthetase	aspartyl-tRNA synthetase 2, mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Microtubule Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	TRNA Binding Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Metal Ion Binding	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Gene Expression Diadenosine Tetraphosphate Biosynthetic Process Viral Process	TRNA Aminoacylation For Protein Translation Gene Expression TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation	tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs		L-Lysine
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AIMP2 DARS2 EEF1D EEF1G FRS3 GAPDH GEMIN4 MAPK1 MAPK14 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 VIM	4 interactors: AIMP2 DPYSL5 EPHA8 KARS
Entrez ID		3735	55157
HPRD ID		03249	07677
Ensembl ID		ENSG00000065427	ENSG00000117593
Uniprot IDs		Q15046	Q6PI48 Q9H9J7
PDB IDs		3BJU 4DPG	4AH6
Enriched GO Terms of Interacting Partners?		Apoptotic Process Retrograde Axon Cargo Transport Programmed Cell Death Cell Death Death Small Molecule Metabolic Process Translation Activation Of MAPK Activity Biosynthetic Process Translational Elongation Enzyme Linked Receptor Protein Signaling Pathway NcRNA Metabolic Process Platelet Activation Organelle Organization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of MAP Kinase Activity Viral Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Osteoclast Differentiation Cellular Protein Metabolic Process Gliogenesis Gene Expression Axon Cargo Transport Regulation Of MAPK Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmission Of Nerve Impulse Cellular Metabolic Process Cellular Response To Organic Substance Activation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Mitochondrial Asparaginyl-tRNA Aminoacylation Response To Antipsychotic Drug Peptidyl-cysteine S-trans-nitrosylation P38MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Response To Other Organism Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Lysyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process TRNA Metabolic Process Type II Pneumocyte Differentiation Pyrimidine Nucleobase Catabolic Process Neuron Remodeling Axon Guidance Lung Secretory Cell Differentiation Cellular Amino Acid Metabolic Process NcRNA Metabolic Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Small Molecule Metabolic Process Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Translation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Maturation Cell Morphogenesis Involved In Differentiation Substrate-dependent Cell Migration Pyrimidine Nucleobase Metabolic Process Regulation Of Cell Adhesion Mediated By Integrin Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Development Lung Epithelial Cell Differentiation Regulation Of Lipid Kinase Activity Carboxylic Acid Metabolic Process Lung Cell Differentiation Cell Differentiation Cell Morphogenesis Lung Epithelium Development Neuron Differentiation Organic Acid Metabolic Process Cell Projection Organization Locomotion Ephrin Receptor Signaling Pathway
Tagcloud ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Difference) ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Intersection) ?