KARS1 and MIR200C

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		KARS1	MIR200C
Description		lysyl-tRNA synthetase 1	microRNA 200c
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	RISC Complex
	Molecular Function	TRNA Binding Nucleotide Binding Nucleic Acid Binding ATP:ADP Adenylyltransferase Activity Aminoacyl-tRNA Ligase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Transferase Activity Ligase Activity Identical Protein Binding Protein Homodimerization Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Basophil Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Antigenic Stimulus Translation TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Response To X-ray Diadenosine Tetraphosphate Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of DNA-templated Transcription ERK1 And ERK2 Cascade	Negative Regulation Of Cytokine Production Positive Regulation Of Neuron Projection Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Endoplasmic Reticulum Stress MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Cardiac Muscle Contraction Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Interleukin-33 Production Response To Amyloid-beta Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Lysine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Interacting Genes		87 interacting genes: AIMP2 CDC42 CEBPA DARS2 DYSF EEF1D EEF1G ESR1 FNDC3B FRS3 GAPDH GEMIN4 LINC01554 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-2 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 SUMO2 VIM	89 interacting genes: AIMP2 AQR ATXN2L C1QBP CHERP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EDC4 EIF2AK2 ELAC1 EPRS1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT16L1 NUFIP2 PDCD11 PTBP1 PTBP3 PTCD3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM56 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		3735	406985
HPRD ID		03249
Ensembl ID		ENSG00000065427	ENSG00000207713
Uniprot IDs		Q15046
PDB IDs		3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH 7EA9 8HYR 8XP4 9DOW 9DPA 9DPB 9DPL
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation Negative Regulation Of Cell Migration MRNA Destabilization Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Translation Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Regulation Of Cell Migration Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vasculature Development Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Locomotion Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm Nucleus Spliceosomal Complex Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation MiRNA Binding Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Gene Expression RNA Stabilization TRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MRNA Stabilization U2 SnRNP Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Positive Regulation Of Cytoplasmic Translation Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Positive Regulation Of Gene Expression CRD-mediated MRNA Stabilization Nucleolus TRNA Aminoacylation MRNA 5'-UTR Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome U2-type Prespliceosome Assembly
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