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KARS1 and AIMP2
Number of citations of the paper that reports this interaction (PubMedID
35235311
)
31
Data Source:
BioGRID
(cross-linking study)
HPRD
(two hybrid)
KARS1
AIMP2
Description
lysyl-tRNA synthetase 1
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Nucleus
Cytoplasm
Cytosol
Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Molecular Function
TRNA Binding
Nucleotide Binding
Nucleic Acid Binding
ATP:ADP Adenylyltransferase Activity
Aminoacyl-tRNA Ligase Activity
Lysine-tRNA Ligase Activity
Protein Binding
ATP Binding
Amino Acid Binding
Transferase Activity
Ligase Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Binding
Protein-macromolecule Adaptor Activity
Molecular Adaptor Activity
Biological Process
Basophil Activation Involved In Immune Response
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Translation
TRNA Aminoacylation For Protein Translation
Lysyl-tRNA Aminoacylation
TRNA Processing
Response To X-ray
Diadenosine Tetraphosphate Biosynthetic Process
Positive Regulation Of Macrophage Activation
Positive Regulation Of DNA-templated Transcription
ERK1 And ERK2 Cascade
Translation
Apoptotic Process
Negative Regulation Of Cell Population Proliferation
Protein Ubiquitination
Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Neuron Apoptotic Process
Type II Pneumocyte Differentiation
Protein-containing Complex Assembly
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Mitochondrial tRNA aminoacylation
Transcriptional and post-translational regulation of MITF-M expression and activity
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Lysine
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Interacting Genes
87 interacting genes:
AIMP2
CDC42
CEBPA
DARS2
DYSF
EEF1D
EEF1G
ESR1
FNDC3B
FRS3
GAPDH
GEMIN4
LINC01554
MAPK1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-2
MIR18B
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR25
MIR29A
MIR29B1
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
OGT
PAFAH1B1
PIK3R3
RPSA
SLC25A6
SOD1
SPTAN1
SUMO2
VIM
103 interacting genes:
AIMP1
APP
BCAS2
BEX3
BLOC1S4
BRME1
BYSL
C1orf216
CBY2
CEBPA
CEP126
CHD3
DARS1
DARS2
DEAF1
DISC1
DRC12
DSN1
EPRS1
EPS8
EXOC8
FGB
FHL3
FILNC1
FUBP1
GYS1
ICE1
KARS1
KDR
KLC2
KRT31
KRT33B
KRT34
KRT36
LMO2
LMO3
LNX1
LUC7L2
MATR3
MCF2L
MIR106A
MIR107
MIR122
MIR128-1
MIR128-2
MIR138-2
MIR15A
MIR18A
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200C
MIR205
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR34A
MIR34B
MIR34C
MIR429
MIR451A
MIR7-1
MIR7-2
MIR92A2
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7I
MIS18A
NDEL1
NECAB2
NTAQ1
PFDN6
PLEKHF2
PPP2R1A
PRKAA2
PRKN
PSME1
RABEP1
SBK3
SLU7
SMURF2
SPATA18
TANK
TCP11
TERF2IP
TEX12
TFIP11
TRAF2
TRMT2A
ZC3H12A
ZGPAT
Entrez ID
3735
7965
HPRD ID
03249
02915
Ensembl ID
ENSG00000065427
ENSG00000106305
Uniprot IDs
Q15046
A8MU58
Q13155
PDB IDs
3BJU
4DPG
4YCU
4YCW
6CHD
6ILD
6ILH
7EA9
8HYR
8XP4
9DOW
9DPA
9DPB
9DPL
4DPG
4YCU
4YCW
5A1N
5A34
5A5H
5Y6L
6ILD
6IY6
6JPV
6K39
8J9S
9DPL
Enriched GO Terms of Interacting Partners
?
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Biosynthetic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Negative Regulation Of Biosynthetic Process
Extracellular Vesicle
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
MRNA Destabilization
Negative Regulation Of Cell Motility
RNA Destabilization
Negative Regulation Of Locomotion
Positive Regulation Of MRNA Catabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of MRNA Metabolic Process
Regulation Of MRNA Stability
Regulation Of Translation
Negative Regulation Of Cytokine Production
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Stability
Regulation Of Cell Migration
Regulation Of Angiogenesis
Negative Regulation Of Angiogenesis
Regulation Of Vasculature Development
Negative Regulation Of Vasculature Development
Regulation Of Cell Motility
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Locomotion
Negative Regulation Of Developmental Process
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Endothelial Cell Migration
Regulation Of Metabolic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Regulation Of MRNA Metabolic Process
Negative Regulation Of Signal Transduction
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Extracellular Vesicle
Negative Regulation Of Gene Expression
MiRNA-mediated Gene Silencing By MRNA Destabilization
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
MRNA Destabilization
RNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Translation
Regulation Of MRNA Stability
Regulation Of Angiogenesis
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Regulation Of Vasculature Development
Regulation Of RNA Stability
Negative Regulation Of Cytokine Production
Negative Regulation Of Signal Transduction
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Protein Metabolic Process
Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Catabolic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Sprouting Angiogenesis
Extracellular Space
Regulation Of Macromolecule Metabolic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of MRNA Metabolic Process
Negative Regulation Of Cell Migration
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Motility
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Tagcloud (Difference)
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Tagcloud (Intersection)
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