KARS and SLC25A6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KARS	SLC25A6
Gene Name		lysyl-tRNA synthetase	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Microtubule Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Inner Membrane Presequence Translocase Complex Integral Component Of Membrane
	Molecular Function	TRNA Binding Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Metal Ion Binding	ATP:ADP Antiporter Activity Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Gene Expression Diadenosine Tetraphosphate Biosynthetic Process Viral Process	Energy Reserve Metabolic Process Protein Targeting To Mitochondrion Apoptotic Process ADP Transport ATP Transport Viral Process Modulation By Virus Of Host Morphology Or Physiology Viral Life Cycle Cellular Protein Metabolic Process Small Molecule Metabolic Process Active Induction Of Host Immune Response By Virus Regulation Of Insulin Secretion Transmembrane Transport
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation	Integration of energy metabolism Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization HIV Infection Regulation of insulin secretion Host Interactions of HIV factors Mitochondrial protein import Host Interactions with Influenza Factors Influenza Infection Influenza Virus Induced Apoptosis Interactions of Vpr with host cellular proteins
Drugs		L-Lysine	Clodronate
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AIMP2 DARS2 EEF1D EEF1G FRS3 GAPDH GEMIN4 MAPK1 MAPK14 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 VIM	18 interactors: AP2B1 CHGB FGFR3 KARS KRT31 KRTAP4-12 LZTS2 MID2 MTUS2 NOTCH2NL PLSCR1 PRSS23 STRN4 TEKT4 TRAF1 TRIM23 TRIP6 VIM
Entrez ID		3735	293
HPRD ID		03249	02461
Ensembl ID		ENSG00000065427
Uniprot IDs		Q15046	P12236 Q6I9V5
PDB IDs		3BJU 4DPG
Enriched GO Terms of Interacting Partners?		Apoptotic Process Retrograde Axon Cargo Transport Programmed Cell Death Cell Death Death Small Molecule Metabolic Process Translation Activation Of MAPK Activity Biosynthetic Process Translational Elongation Enzyme Linked Receptor Protein Signaling Pathway NcRNA Metabolic Process Platelet Activation Organelle Organization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of MAP Kinase Activity Viral Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Osteoclast Differentiation Cellular Protein Metabolic Process Gliogenesis Gene Expression Axon Cargo Transport Regulation Of MAPK Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmission Of Nerve Impulse Cellular Metabolic Process Cellular Response To Organic Substance Activation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Mitochondrial Asparaginyl-tRNA Aminoacylation Response To Antipsychotic Drug Peptidyl-cysteine S-trans-nitrosylation P38MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Response To Other Organism Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging	Lens Fiber Cell Development Lens Fiber Cell Differentiation Viral Process Lysyl-tRNA Aminoacylation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Viral Process Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Signaling Lens Development In Camera-type Eye Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Glial Cell Development Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical	aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rps4x rq scnt somatic telomerase transcript transfer twin xiap xist zfx
Tagcloud (Difference) ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical	aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rps4x rq scnt somatic telomerase transcript transfer twin xiap xist zfx
Tagcloud (Intersection) ?