KARS and SOD1

Number of citations of the paper that reports this interaction (PMID 18715867)
9

Data Source:
HPRD (in vivo)

		KARS	SOD1
Gene Name		lysyl-tRNA synthetase	superoxide dismutase 1, soluble
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Microtubule Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Peroxisome Cytosol Plasma Membrane Extracellular Matrix Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Protein Complex Extracellular Vesicular Exosome
	Molecular Function	TRNA Binding Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Metal Ion Binding	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Protein Phosphatase 2B Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding Chaperone Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Gene Expression Diadenosine Tetraphosphate Biosynthetic Process Viral Process	Activation Of MAPK Activity Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Platelet Degranulation Glutathione Metabolic Process Superoxide Metabolic Process Cellular Iron Ion Homeostasis Spermatogenesis Embryo Implantation Cell Aging Blood Coagulation Sensory Perception Of Sound Locomotory Behavior Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Regulation Of Blood Pressure Response To Heat Response To Organic Substance Transmission Of Nerve Impulse Removal Of Superoxide Radicals Platelet Activation Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Regulation Of Rac GTPase Activity Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Drug Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Protein Kinase Activity Regulation Of Organ Growth Response To Antibiotic Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Regulation Of Mitochondrial Membrane Potential Oxidation-reduction Process Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation	Response to elevated platelet cytosolic Ca2+ Detoxification of Reactive Oxygen Species Platelet degranulation Platelet activation, signaling and aggregation
Drugs		L-Lysine
Diseases
GWAS			Amyotrophic lateral sclerosis ( 20801718)
Protein-Protein Interactions		15 interactors: AIMP2 DARS2 EEF1D EEF1G FRS3 GAPDH GEMIN4 MAPK1 MAPK14 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 VIM	14 interactors: AMFR BCL2 CCS CRYAB DNAJB1 HOXB2 HSPA4 KARS MARCH5 PARK7 PPP3CA RNF19A SMAD2 UBE3A
Entrez ID		3735	6647
HPRD ID		03249	00937
Ensembl ID		ENSG00000065427	ENSG00000142168
Uniprot IDs		Q15046	P00441
PDB IDs		3BJU 4DPG	1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4SOD
Enriched GO Terms of Interacting Partners?		Apoptotic Process Retrograde Axon Cargo Transport Programmed Cell Death Cell Death Death Small Molecule Metabolic Process Translation Activation Of MAPK Activity Biosynthetic Process Translational Elongation Enzyme Linked Receptor Protein Signaling Pathway NcRNA Metabolic Process Platelet Activation Organelle Organization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of MAP Kinase Activity Viral Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Osteoclast Differentiation Cellular Protein Metabolic Process Gliogenesis Gene Expression Axon Cargo Transport Regulation Of MAPK Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmission Of Nerve Impulse Cellular Metabolic Process Cellular Response To Organic Substance Activation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Mitochondrial Asparaginyl-tRNA Aminoacylation Response To Antipsychotic Drug Peptidyl-cysteine S-trans-nitrosylation P38MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Response To Other Organism Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging	Cellular Protein Metabolic Process Protein Polyubiquitination Response To Reactive Oxygen Species Response To Inorganic Substance Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Organ Growth Response To Organic Substance Reactive Oxygen Species Metabolic Process Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Regulation Of Protein Homodimerization Activity Response To Unfolded Protein Negative Regulation Of Transport Response To Oxidative Stress Regulation Of Intracellular Transport Cellular Response To Stress Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Mitochondrial Membrane Potential Cellular Response To Oxidative Stress Positive Regulation Of Oxidoreductase Activity Response To Stress Protein Autoubiquitination Regulation Of Binding Response To Gamma Radiation Regulation Of Cellular Component Organization Neural Nucleus Development Regulation Of Membrane Potential Developmental Growth Positive Regulation Of Mitochondrion Organization Mitochondrial Membrane Organization Lysyl-tRNA Aminoacylation Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Sperm Entry Negative Regulation Of Cellular PH Reduction Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Transition Between Fast And Slow Fiber CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity
Tagcloud ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical	alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic
Tagcloud (Difference) ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical	alteration amyotrophic autosomal axonal became dismutase dysfunctions electromyographic familial fibrillation g93a gastrocnemius hindlimb latencies motor myelin neuromuscular p100 p120 p130 p63 p90 potentials progressively quantify recordings striking superoxide transgenic
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