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MNAT1
Description
MNAT1 component of CDK activating kinase
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIIH Holo Complex
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Molecular Function
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
DNA Repair
Nucleotide-excision Repair
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Adult Heart Development
Ventricular System Development
Negative Regulation Of Apoptotic Process
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To Calcium Ion
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS
Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease (
29631575
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Refractive error (
32231278
)
Interacting Genes
50 interacting genes:
BEX3
BRCA1
CDK7
COPS6
DMAP1
DSCAM
E2F1
EEF1A1
ERCC3
ERG
ESR1
FOXP1
GOLGA2
GTF2E2
GTF2H1
HMGB1
HPS6
LRIF1
MAGEC2
MAGEE2
MCM7
MDM4
MKRN3
MTA1
NKX3-1
POLR2A
POU2F1
POU2F2
POU5F1
RB1
RBM48
RNF32
RNF41
RNF7
SUPT5H
TET2
TP53
TRIM14
TRIM17
TRIM2
TRIM21
TRIM26
TRIM31
TRIM34
TRIM39
TRIM5
TRIM9
TRIML1
UBC
USP2
Entrez ID
4331
HPRD ID
04042
Ensembl ID
ENSG00000020426
Uniprot IDs
A0A024R688
P51948
PDB IDs
1G25
6NMI
6O9L
6O9M
6TUN
6XBZ
6XD3
7B5O
7B5Q
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVW
7NVX
7NVY
7NVZ
7NW0
8BVW
8BYQ
8GXQ
8GXS
8ORM
8P6V
8P6W
8P6X
8P6Y
8P6Z
8P70
8P71
8P72
8P73
8P74
8P75
8P76
8P77
8P78
8P79
8P7L
8PLZ
8PYR
8S0R
8S0T
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Activity
Macromolecule Metabolic Process
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Zinc Ion Binding
Nucleoplasm
Protein Modification Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Protein Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Nucleus
DNA Damage Response
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Protein Polyubiquitination
Negative Regulation Of RNA Metabolic Process
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Transcription By RNA Polymerase II
Response To Stress
Transcription By RNA Polymerase II
Innate Immune Response
Ubiquitin Protein Ligase Binding
DNA Binding
Negative Regulation Of Macromolecule Metabolic Process
Transcription Factor TFIIH Core Complex
Metal Ion Binding
Cellular Response To Stress
Transcription Factor TFIIH Holo Complex
Sequence-specific DNA Binding
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