MNAT1 and RNF7

Number of citations: 44 (PubMedID 22493164)
Data Source: BioGRID (two hybrid)

		MNAT1	RNF7
Name		MNAT1 component of CDK activating kinase	ring finger protein 7
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Copper Ion Binding Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Repair Nucleotide-excision Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Adult Heart Development Ventricular System Development Negative Regulation Of Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Response To Calcium Ion Regulation Of G1/S Transition Of Mitotic Cell Cycle	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Reelin-mediated Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Phosphocreatine Biosynthetic Process Defense Response To Virus Response To Redox State Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Regulation Of Neuron Migration
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Refractive error ( 32231278 )	Hepatitis C induced liver fibrosis ( 22841784 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )
Interacting Genes		50 interacting genes: BEX3 BRCA1 CDK7 COPS6 DMAP1 DSCAM E2F1 EEF1A1 ERCC3 ERG ESR1 FOXP1 GOLGA2 GTF2E2 GTF2H1 HMGB1 HPS6 LRIF1 MAGEC2 MAGEE2 MCM7 MDM4 MKRN3 MTA1 NKX3-1 POLR2A POU2F1 POU2F2 POU5F1 RB1 RBM48 RNF32 RNF41 RNF7 SUPT5H TET2 TP53 TRIM14 TRIM17 TRIM2 TRIM21 TRIM26 TRIM31 TRIM34 TRIM39 TRIM5 TRIM9 TRIML1 UBC USP2	43 interacting genes: APOBEC3F APOBEC3G ARIH2 ASB11 BTRC CASP7 CBFB CDC34 CHFR CREBBP CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL5 CYCS ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBA3 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 USP40
Entrez ID		4331	9616
HPRD ID		04042	04840
Ensembl ID		ENSG00000020426	ENSG00000114125
Uniprot IDs		A0A024R688 P51948	Q9UBF6
PDB IDs		1G25 6NMI 6O9L 6O9M 6TUN 6XBZ 6XD3 7B5O 7B5Q 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8GXQ 8GXS 8ORM 8P6V 8P6W 8P6X 8P6Y 8P6Z 8P70 8P71 8P72 8P73 8P74 8P75 8P76 8P77 8P78 8P79 8P7L 8PLZ 8PYR 8S0R 8S0T 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	2ECL 7ONI
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Macromolecule Metabolic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Zinc Ion Binding Nucleoplasm Protein Modification Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Transcription By RNA Polymerase II Innate Immune Response Ubiquitin Protein Ligase Binding DNA Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Metal Ion Binding Cellular Response To Stress Transcription Factor TFIIH Holo Complex Sequence-specific DNA Binding	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cullin-RING Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity Nucleus Cell Cycle Phase Transition Cul5-RING Ubiquitin Ligase Complex Protein K11-linked Ubiquitination Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition NEDD8 Transferase Activity Cytosol Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Virus Defense Response To Virus Intracellular Signal Transduction Protein K63-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway NEDD8 Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin-like Protein Transferase Activity Protein Destabilization